Evidence map›Paper›PMID 35572567›Full record

ArticleFrontiers in immunology2022

Sulfadiazine Plus Pyrimethamine Therapy Reversed Multiple Behavioral and Neurocognitive Changes in Long-Term Chronic Toxoplasmosis by Reducing Brain Cyst Load and Inflammation-Related Alterations.

Barrios Leda Castaño, Andrea Alice Silva, Lina L Hernandez-Velasco, Ana Paula Da Silva Pinheiro, Daniel Gibaldi, José Roberto Mineo, Neide Maria Silva, Joseli Lannes-Vieira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Pharmacological assessment of drugs retained in the 1Naunyn-Schmiedeberg's archives of pharmacology · 2026
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  10. Chronic infection by atypicalBrain, behavior, & immunity - health · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Barrios Leda CastañoLaboratory of Biology of the Interactions, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
Andrea Alice SilvaMultiuser Laboratory for Research Support in Nephrology and Medical Sciences, Federal University Fluminense, Niterói, Brazil.
Lina L Hernandez-VelascoFaculty of Basic Sciences, University of Santiago de Cali, Cali, Colombia.
Ana Paula Da Silva PinheiroLaboratory of Biology of the Interactions, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
Daniel GibaldiLaboratory of Biology of the Interactions, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
José Roberto MineoInstitute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Neide Maria SilvaInstitute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, Brazil.
Joseli Lannes-VieiraLaboratory of Biology of the Interactions, Oswaldo Cruz Institute/Fiocruz, Rio de Janeiro, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal de Uberlândia · BRUniversidade Federal Fluminense · BRUniversidad Santiago de Cali · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BrainPyrimethamineSulfadiazineToxoplasmosisAnimalsCytokinesFemaleInflammationMemory DisordersMiceMice, Inbred C57BLCytokinesPyrimethamineSulfadiazineanxietycytokinesdepressionhyperactivitymemory lossneuroinflammationToxoplasma gondii

Identifiers

PMID35572567
PMCPMC9091718
OpenAlexW4285744242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.