Evidence map›Paper›PMID 35572554›Full record

ArticleFrontiers in immunology2022

TLR2/TLR4-Enhanced TIPE2 Expression Is Involved in Post-Hemorrhagic Shock Mesenteric Lymph-Induced Activation of CD4+T Cells.

Hui-Bo Du, Sun-Ban Jiang, Zhen-Ao Zhao, Hong Zhang, Li-Min Zhang, Zhao Wang, Ya-Xiong Guo, Jia-Yi Zhai, Peng Wang, Zi-Gang Zhao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hui-Bo DuInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Sun-Ban JiangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Zhen-Ao ZhaoInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Hong ZhangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Li-Min ZhangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Zhao WangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Ya-Xiong GuoInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Jia-Yi ZhaiInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Peng WangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Zi-Gang ZhaoInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Chun-Yu NiuHebei Key Laboratory of Critical Disease Mechanism and Intervention, Shijiazhuang, China.
Li-Na JiangInstitute of Microcirculation, Hebei North University, Zhangjiakou, China.
Hebei North University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Post hemorrhagic shock mesenteric lymph (PHSML) return contributes to CD4 Methods: The splenic CD4 Results: PHSML stimulation significantly upregulated TIPE2, TLR2, and TLR4 mRNA expressions, decreased proliferation, CD25 expression, and IFN-γ secretion, and increased the secretion ability of IL-4 in WT CD4 Conclusion: TIPE2 improves the PHSML-mediated CD4

Indexed as

Shock, HemorrhagicAnimalsCD4-Positive T-LymphocytesIntracellular Signaling Peptides and ProteinsMiceRNA, MessengerToll-Like Receptor 2Toll-Like Receptor 4Intracellular Signaling Peptides and ProteinsRNA, MessengerTIPE2 protein, mouseTlr2 protein, mouseTlr4 protein, mouseToll-Like Receptor 2Toll-Like Receptor 4CD4+ T lymphocytehemorrhagic shockimmune dysfunctionmesenteric lymphtumor necrosis factor α induced protein 8 like-2

Identifiers

PMID35572554
PMCPMC9101470
OpenAlexW4225153162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.