Evidence map›Paper›PMID 35572533›Full record

SynthesisFrontiers in immunology2022

The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer.

Jinze Li, Dehong Cao, Yin Huang, Qiao Xiong, Daqing Tan, Liangren Liu, Tianhai Lin, Qiang Wei

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  7. ALNCR.TNM as a Novel Prognostic Tool for Cancer Survival.Journal of cachexia, sarcopenia and muscle · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinze LiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Dehong CaoDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Yin HuangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Qiao XiongDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Daqing TanDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Liangren LiuDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Tianhai LinDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Qiang WeiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Systemic immune-inflammation index (SII) has recently emerged as a biomarker for the prognosis of a variety of malignant tumors. However, the role of SII in bladder cancer (BC) remains unclear. To this end, we performed a pooled analysis to investigate the prognostic value of preoperative SII in patients with BC. Methods: A comprehensive search of electronic databases (PubMed/Medline, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials) was conducted to determine the eligible studies that were published until January 2022. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the association between preoperative SII and the prognosis and clinicopathological characteristics of BC. Results: Ten studies with 7,087 patients were included in this analysis. SII was observed to be correlated with inferior overall survival (HR = 1.22, 95% CI 1.04-1.44, p = 0.013), cancer-specific survival (HR = 1.68, 95% CI 1.14-2.47, Conclusions: An elevated preoperative SII is significantly associated with worse survival outcomes and adverse pathological features in patients with BC. Hence, SII may serve as a strong independent prognostic predictor for patients with BC after surgery.

Indexed as

Urinary Bladder NeoplasmsBiomarkersHumansInflammationPrognosisProportional Hazards ModelsBiomarkersbladder cancermeta-analysisprognosissurvivalsystemic immune-inflammation index

Identifiers

PMID35572533
PMCPMC9097688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.