ReviewFrontiers in immunology2022
The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.
Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Strongyloides stercoralis infection in the UK: A systematic review and meta-analysis of published cases.Clinical medicine (London, England) · 2024Pooled it
- In vivo reduction of Treg expansion in rodent helminth-malaria coinfection.Parasites & vectors · 2026Article
- Localization of the Complement C1q-Binding Site onTropical medicine and infectious disease · 2026Article
- Coinfection with malaria alters the fecundity and within-host persistence of an intestinal nematode.PLoS neglected tropical diseases · 2026Article
- Integrating the Microbiome Into Infection Ecology and Evolution in Wild Animals.Molecular ecology · 2026Review
- Effects of Genetic polymorphism in susceptibility to schistosomiasis infection and adverse treatment outcomes.African health sciences · 2025Review
- Review
- 'Re-Wilding' an Animal Model With Microbiota Shifts Immunity and Stress Gene Expression During Infection.Molecular ecology · 2025Article
- Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions.Frontiers in immunology · 2025Review
- Trypanosoma vivax elicits both Th1 and Th2 immunological responses in experimentally infected cattle.PloS one · 2025Article
- Bacilli load in PTB- intestinal helminths co-infected and PTB non -infected patients at selected public health facilities in Jimma zone, Oromia, Ethiopia: comparative cross-sectional study.BMC infectious diseases · 2024Article
- Genetic and environmental interactions contribute to immune variation in rewilded mice.Nature immunology · 2024Article
- Review
- Genetic and Environmental interactions contribute to immune variation in rewilded mice.bioRxiv : the preprint server for biology · 2023Article
- Dual activation profile of monocytes is associated with protection in Mexican patients during SARS-CoV-2 disease.Applied microbiology and biotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Helminth infection currently affect over 2 billion people worldwide, with those with the most pathologies and morbidities, living in regions with unequal and disproportionate access to effective healthcare solutions. Host genetics and environmental factors play critical roles in modulating and regulating immune responses following exposure to various pathogens and insults. However, the interplay of environment and genetic factors in influencing who gets infected and the establishment, persistence, and clearance of helminth parasites remains unclear. Inbred strains of mice have long been used to investigate the role of host genetic factors on pathogenesis and resistance to helminth infection in a laboratory setting. This review will discuss the use of ecological and environmental mouse models to study helminth infections and how this could be used in combination with host genetic variation to explore the relative contribution of these factors in influencing immune response to helminth infections. Improved understanding of interactions between genetics and the environment to helminth immune responses would be important for efforts to identify and develop new prophylactic and therapeutic options for the management of helminth infections and their pathogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.