Evidence map›Paper›PMID 35572424›Full record

ArticleJSES international2022

Caffeine intake does not appear to impair tendon-to-bone healing strength in a rat rotator cuff repair model.

Bradley L Young, Evan D Sheppard, Sierra Phillips, Trevor M Stubbs, Jun Kit He, Andrew Moon, Martim C Pinto, Gerald McGwin, Eugene William Brabston, Shawn R Gilbert and 1 more

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Article in JSES international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bradley L YoungAtrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, NC, USA.
Evan D SheppardDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Sierra PhillipsDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Trevor M StubbsDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Jun Kit HeDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Andrew MoonDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Martim C PintoDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Gerald McGwinSchool of Public Health, Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Eugene William BrabstonDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Shawn R GilbertDepartment of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham AL, USA.
Brent A PonceHughston Orthopaedic Clinic, Columbus, GA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tendon-to-bone (TtB) healing is essential for successful rotator cuff repair (RCR). This study aimed to investigate if caffeine intake impaired TtB healing in a rat RCR model. Methods: Seventy-two rats were randomized into a caffeinated group or a noncaffeinated group. Specimens received one week of oral caffeine solution or normal saline before RCR. All rats then underwent bilateral RCR. Caffeination or saline gavages continued until rats were sacrificed at 2, 4, and 8 weeks postoperatively. Load-to-failure (primary outcomes measure), maximum stress, and stiffness of the TtB interface were measured for one shoulder of each specimen. Six random shoulders from each group underwent histological assessment of TtB healing. Results: Load-to-failure and maximum stress of RCR did not appear to differ between groups at any time point. No difference in RCR stiffness was found between groups at 2 and 4 weeks; however, stiffness in the caffeinated group did appear to lower at 8 weeks ( Conclusion: Perioperative caffeine intake did not appear to affect load-to-failure strength of RCR in an animal model. Although our secondary outcome measures of maximum stress and stiffness also did not appear to be influenced by perioperative caffeine intake, there did appear to be a trend toward decreased RCR stiffness at 8 weeks postoperatively in specimens that received caffeine.

Indexed as

Basic science studyCaffeineRotator cuff healingRotator cuff repairTendon to bone healing

Identifiers

PMID35572424
PMCPMC9091803

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.