ArticleJournal of advanced research2022
High value-added application of a renewable bioresource as acaricide: Investigation the mechanism of action of scoparone against
Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 27 citations in OpenAlex.
- Activity Against Pythium insidiosum and Isolated Constituents of Cordia insignis Roots.Chemistry & biodiversity · 2026Article
- A Comprehensive Multiomics Approach Illuminates the Biosynthetic Mechanism of Scoparone in Artemisia capillaris.Plant biotechnology journal · 2026Article
- Natural Coumarin Shows Toxicity toInternational journal of molecular sciences · 2023Article
- Contact Toxicity, Antifeedant Activity, and Oviposition Preference of Osthole against Agricultural Pests.Insects · 2023Article
- Mediterranean Plants as Potential Source of Biopesticides: An Overview of Current Research and Future Trends.Metabolites · 2023Review
- The Insecticidal Efficacy and Physiological Action Mechanism of a Novel Agent GC16 againstInsects · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Investigation into the action mechanisms of plant secondary metabolites against pests is a vital strategy for the development of novel promising biopesticides. Scoparone (isolated from Objectives: This study aimed to systematically explore the potential molecular targets of scoparone against Methods: The mechanism and potential targets of scoparone against mites were investigated using RNA-seq analysis; RNA interference (RNAi) assays; bioassays; and [Ca Results: RNA-seq analysis identified Ca Conclusion: This study demonstrates, for the first time, that the acaricidal compound scoparone targets the interface between CaM1 and L-VGCC and activates the CaM-binding site, located in the IQ motif at the L-VGCC C-terminus. This work may contribute to the development of target-specific green acaricidal compounds based on L-VGCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.