Evidence map›Paper›PMID 35572151›Full record

ArticleFrontiers in aging neuroscience2022

The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the

Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C J Hofmann, Nina Pannwitz, Eduard Resch, Sonja Luckhardt, Ann-Kathrin Schneider, Sandra Trautmann, Yannick Schreiber and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Homocysteine Attack on Vascular Endothelium-Old and New Features.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Hendrik NieraadFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Natasja de BruinFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Olga ArneFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Martine C J HofmannFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Nina PannwitzFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Eduard ReschFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Sonja LuckhardtFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Ann-Kathrin SchneiderFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Sandra TrautmannPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany.
Yannick SchreiberFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Robert GurkeFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Michael J ParnhamFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Uwe TillFormer Institute of Pathobiochemistry, Friedrich-Schiller-Universität Jena, Jena, Germany.
Gerd GeisslingerFraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology · DEGoethe University Frankfurt · DEEndo Pharmaceuticals (United States) · USFriedrich Schiller University Jena · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A causal contribution of hyperhomocysteinemia to cognitive decline and Alzheimer's disease (AD), as well as potential prevention or mitigation of the pathology by dietary intervention, have frequently been subjects of controversy. In the present

Indexed as

Alzheimer’s diseaseamyloid betapeptideshyperhomocysteinemiamemory and learning testsproteomicsvitamin B deficiency

Identifiers

PMID35572151
PMCPMC9094364
OpenAlexW4224947046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.