ArticleFrontiers in aging neuroscience2022
Structural and Functional Trajectories of Middle Temporal Gyrus Sub-Regions During Life Span: A Potential Biomarker of Brain Development and Aging.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Altered cortical neuronal activity in functional esophageal disorders and its associations with chronic insomnia and peripheral inflammation: a resting-state fMRI study.Frontiers in molecular neuroscience · 2026Article
- Insights into structural deviations in attention deficit hyperactivity disorder (ADHD) and comorbidities using big data-derived brain charts: a cross-sectional study.Quantitative imaging in medicine and surgery · 2025Article
- Recognition of flight cadets brain functional magnetic resonance imaging data based on machine learning analysis.PloS one · 2025Article
- A network approach to the investigation of childhood irritability: probing frustration using social stimuli.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Dynamic weighted hypergraph convolutional network for brain functional connectome analysis.Medical image analysis · 2023Article
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7 authors.
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Abstract
Although previous studies identified a similar topography pattern of structural and functional delineations in human middle temporal gyrus (MTG) using healthy adults, trajectories of MTG sub-regions across lifespan remain largely unknown. Herein, we examined gray matter volume (GMV) and resting-state functional connectivity (RSFC) using datasets from the Nathan Kline Institute (NKI), and aimed to (1) investigate structural and functional trajectories of MTG sub-regions across the lifespan; and (2) assess whether these features can be used as biomarkers to predict individual's chronological age. As a result, GMV of all MTG sub-regions followed U-shaped trajectories with extreme age around the sixth decade. The RSFC between MTG sub-regions and many cortical brain regions showed inversed U-shaped trajectories, whereas RSFC between MTG sub-regions and sub-cortical regions/cerebellum showed U-shaped way, with extreme age about 20 years earlier than those of GMV. Moreover, GMV and RSFC of MTG sub-regions could be served as useful features to predict individual age with high estimation accuracy. Together, these results not only provided novel insights into the dynamic process of structural and functional roles of MTG sub-regions across the lifespan, but also served as useful biomarkers to age prediction.
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