Evidence map›Paper›PMID 35572125›Full record

ArticleFrontiers in aging neuroscience2022

Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured

Jenny R Diaz, Mitchell Martá-Ariza, Alireza Khodadadi-Jamayran, Adriana Heguy, Aristotelis Tsirigos, Joanna E Pankiewicz, Patrick M Sullivan, Martin J Sadowski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Analysis of Neurite and Spine Formation in Neurons In Vitro.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jenny R DiazDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United States.
Mitchell Martá-ArizaDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United States.
Alireza Khodadadi-JamayranDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, United States.
Adriana HeguyDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, United States.
Aristotelis TsirigosDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, United States.
Joanna E PankiewiczDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United States.
Patrick M SullivanDepartment of Medicine (Geriatrics), Duke University School of Medicine, Durham, NC, United States.
Martin J SadowskiDepartment of Neurology, New York University Grossman School of Medicine, New York, NY, United States.
New York University · USGeriatric Research Education and Clinical Center · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Targeting the apoE/A-beta Interaction as a Therapeutic Approach for ADR01AG031221 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SADOWSKI, MARTIN JOSEPH · 2008 to 2020
$4.0M
Role of Microglia in Neurodegeneration -Effect of ApoER01AG075840 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARTIN Joseph SADOWSKI · 2022 to 2026
$3.4M
Mechanisms of Apolipoprotein E Isoform Conferred Susceptibility and Resistance to Alzheimer's DiseaseR01AG053990 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SADOWSKI, MARTIN JOSEPH · 2016 to 2020
$2.1M
Mechanisms of Peroxiredoxin 6 Endowed Protection in Alzheimer’s DiseaseR01AG067478 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SADOWSKI, MARTIN JOSEPH · 2020 to 2024
$2.1M
NCI NIH HHS P30 CA016087NIA NIH HHS R01 AG031221NIA NIH HHS R01 AG053990NIA NIH HHS R01 AG067478NIA NIH HHS R01 AG075840
6 · The paper itself

Abstract

The

Indexed as

Alzheimer’s diseaseApoEgene ontology analysisKEGG enrichment analysisneurodegenerationprimary hippocampal cell culturessynaptic plasticitytranscriptome

Identifiers

PMID35572125
PMCPMC9099260
OpenAlexW4225122407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.