ArticleNature cardiovascular research2022
A High-Efficiency AAV for Endothelial Cell Transduction Throughout the Central Nervous System.
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Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed, 98 citations in OpenAlex.
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- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
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- Endothelial Cell TRIM47 Triggers Blood-Brain Barrier Disruption via CYLD Ubiquitination Degradation in an Intracerebral Hemorrhage Model.Neuroscience bulletin · 2026Article
- Shifting AAV9 tropism by binding moiety insertion enhances transduction of tumor cell lines and human glioblastoma explants.Scientific reports · 2026Article
- Sonoselective Transfection of Glioma Endothelium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Rational design of hammerhead ribozymes as CD93 silencing tools for vascular diseases.Molecular therapy. Nucleic acids · 2026Article
- Towards precision medicine for brain arteriovenous malformations.The Journal of clinical investigation · 2026Review
- Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial-Endothelial Crosstalk in Cardiometabolic Disease: Mechanisms and Translational Opportunities in the Multi-omics Era.Reviews in cardiovascular medicine · 2026Review
- Cerebral capillary computation.American journal of physiology. Cell physiology · 2026Review
- Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline.Nature aging · 2026Article
- Optogenetic Strategies for Motor Recovery After Ischemic Stroke: Mechanisms and Therapeutic Implications.Cellular and molecular neurobiology · 2026Review
- Endocytosis at the mouse blood brain barrier is elevated during sleep.bioRxiv : the preprint server for biology · 2026Article
- Identification of Recombinant Adeno-Associated Virus Serotypes by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.Analytical chemistry · 2026Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Trevor KrolakDepartment of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Ken Y ChanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Luke KaplanDepartment of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Qin HuangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason WuStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Qingxia ZhengStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Velina KozarevaStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Thomas BeddowStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Isabelle G TobeyStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Simon PacouretStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Albert T ChenStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yujia A ChanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel RyvkinDepartment of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Chenghua GuDepartment of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Benjamin E DevermanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Broad Institute · USHoward Hughes Medical Institute · US
Funding
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MMolecular Mechanisms of the Blood Brain Barrier Function and RegulationR35NS116820 · NINDS · HARVARD MEDICAL SCHOOL · PI CHENGHUA GU · 2020 to 2026
$7.0MDevelopment and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species.UG3MH120096 · NIMH · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E, FISHELL, GORDON J · 2019 to 2021
$6.7MSuper-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI REGEHR, WADE G · 2011 to 2020
$5.8MNovel AAVs Engineered for Efficient and Noninvasive Cross-Species Gene Editing Throughout the Central Nervous SystemUH3NS111689 · NINDS · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2021 to 2022
$2.7MNovel AAVs engineered for efficient and noninvasive cross-species gene editing throughout the central nervous systemUG3NS111689 · NINDS · BROAD INSTITUTE, INC. · PI DEVERMAN, BENJAMIN E · 2018 to 2020
$2.5MValidated tools for identifying, characterizing, and targeting all non-neuronal cells in the brain and determining the neuro-glio-vascular connectomeRF1DA048786 · NIDA · HARVARD MEDICAL SCHOOL · PI GU, CHENGHUA · 2019 to 2019
$2.5MNeuronal and vascular interactions in the CNSR01HL153261 · NHLBI · HARVARD MEDICAL SCHOOL · PI GU, CHENGHUA · 2020 to 2023
$2.3MHoward Hughes Medical InstituteNHLBI NIH HHS R01 HL153261NICHD NIH HHS P50 HD105351NIDA NIH HHS RF1 DA048786NIMH NIH HHS UG3 MH120096NINDS NIH HHS P30 NS072030NINDS NIH HHS R35 NS116820NINDS NIH HHS UG3 NS111689NINDS NIH HHS UH3 NS111689
Abstract
Endothelial cells have a crucial role in nervous system function, and mounting evidence points to endothelial impairment as a major contributor to a wide range of neurological diseases. However, tools to genetically interrogate these cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.