Evidence map›Paper›PMID 35571573›Full record

ArticleOTO open

Local Tumor Behavior Associated With Survival Among Patients With Paraganglioma of the Head and Neck.

Randall J Harley, Jason H Lee, Benjamin T Ostrander, Andrey Finegersh, Tammy B Pham, Kareem O Tawfik, Yin Ren, Farhoud Faraji, Rick A Friedman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OTO open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Laryngeal Paraganglioma-A Case Report.Medicina (Kaunas, Lithuania) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Randall J HarleyDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.ORCID https://orcid.org/0000-0002-8519-5366
Jason H LeeDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
Benjamin T OstranderDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
Andrey FinegershDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
Tammy B PhamDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
Kareem O TawfikDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
Yin RenDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
Farhoud FarajiDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.ORCID https://orcid.org/0000-0001-5078-813X
Rick A FriedmanDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California San Diego Health, San Diego, California, USA.
UC San Diego Health System · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of this study was to evaluate the utility of Study Design: Retrospective cohort study. Setting: National Cancer Database between 2004 and 2016. Methods: This study included patients aged ≥18 years who were diagnosed with HNP. Clinical outcomes and clinicopathologic features were compared with regard to local tumor behavior. Results: Our study included 525 patients, of which the majority had HNP classified as locally invasive (45.9%) or borderline (37.9%). The most common anatomic sites involved were the carotid body (33.7%), intracranial regions (29.0%), or cranial nerves (25.5%). Carotid body tumors were exclusively locally invasive, whereas intracranial and cranial nerve HNP were overwhelmingly benign or borderline (94% and 91%, respectively). One-fourth of patients underwent pathologic analysis of regional lymph nodes, of which the majority were positive for metastasis (80.6%). Metastasis to distant organs was twice as common in patients with locally invasive tumors vs benign (15% vs 7.1). For benign disease, surgery with radiotherapy (adjusted hazard ratio [aHR], 40.45; Conclusion: While criteria for tumor behavior could not be defined, our results suggest that such a classification system could be used to enhance HNP risk stratification and guide clinical management decisions.

Indexed as

invasiveparagangliomaprognosisregional lymph nodessurvivaltreatment trends

Identifiers

PMID35571573
PMCPMC9096223
OpenAlexW4226084165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.