Evidence map›Paper›PMID 35571568›Full record

ReviewJournal of immunology research2022

Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer.

Loredana Maria Himiniuc, Bogdan Florin Toma, Razvan Popovici, Ana Maria Grigore, Alexandru Hamod, Constantin Volovat, Simona Volovat, Irina Nica, Decebal Vasincu, Maricel Agop and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. The potential role of miR-155 in the tumorigenesis of cervical cancer.Frontiers in cell and developmental biology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Loredana Maria Himiniuc"Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0002-4721-4642
Bogdan Florin Toma"Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0003-3872-3274
Razvan PopoviciDepartment of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0002-2498-357X
Ana Maria Grigore"Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0001-8580-5489
Alexandru HamodRegional Institute of Oncology, 700483 Iasi, Romania.ORCID https://orcid.org/0000-0003-2494-1801
Constantin VolovatCenter of Oncology Euroclinic, 700110 Iasi, Romania.ORCID https://orcid.org/0000-0003-1582-0135
Simona VolovatCenter of Oncology Euroclinic, 700110 Iasi, Romania.ORCID https://orcid.org/0000-0001-7084-6333
Irina NicaDepartment of Odontology, Periodontics and Fixed Restoration, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0003-1189-0785
Decebal VasincuDepartment of Dental and Oro-Maxillo-Facial Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0002-7139-0304
Maricel AgopDepartment of Physics, "Gheorghe Asachi" Technical University of Iasi, Iasi 700050, Romania.ORCID https://orcid.org/0000-0003-2293-5803
Mihaela TirnovanuDepartment of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0002-7082-8749
Lacramioara OchiuzDepartment of Pharmaceutical and Biotechnological Drug Industry, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0001-6447-0958
Anca NeguraOncogenetics Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.ORCID https://orcid.org/0000-0002-1230-0196
Mihaela GrigoreDepartment of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi 700115, Romania.ORCID https://orcid.org/0000-0002-6530-6874
Grigore T. Popa University of Medicine and Pharmacy · ROAcademia Oamenilor de Știință din România · ROAlexandru Ioan Cuza University · ROInstitutul Regional de Oncologie · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, they highly increase the toxicity in the targeted cervical tumor cells or tissues by linking to specific ligands. In addition, a nondifferentiable model is proposed through holographic implementation in the dynamics of drug delivery dynamics. As any hologram functions as a deep learning process, the artificial intelligence can be proposed as a new analyzing method in cervical cancer.

Indexed as

Antineoplastic AgentsNanoparticlesUterine Cervical NeoplasmsArtificial IntelligenceDrug CarriersDrug Delivery SystemsFemaleHumansAntineoplastic AgentsDrug Carriers

Identifiers

PMID35571568
PMCPMC9095399
OpenAlexW4229024544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.