Evidence map›Paper›PMID 35571459›Full record

ArticleTranslational medicine communications2022

Association of the rs4646994 in

Débora C R F Porchera, Diana F V B Leal, Ana C O Braga, Pablo D C Pinto, Mayara N Santana da Silva, Lucas C Bezerra Santos, Cintia H Braga da Silva, Giovana E da Costa, Maria Clara da C Barros, Aidalucy do S C de Athayde and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational medicine communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A polymorphism in the FAM13A gene confers protection against tuberculosis in Brazilian workers exposed to silica.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025
    Article
  2. Polymorphisms in the ACE I/D (Tropical medicine and infectious disease · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Débora C R F PorcheraLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Diana F V B LealNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Ana C O BragaNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Pablo D C PintoLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Mayara N Santana da SilvaLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Lucas C Bezerra SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Cintia H Braga da SilvaLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Giovana E da CostaNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Maria Clara da C BarrosNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Aidalucy do S C de AthaydeNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Amanda de N Cohen-PaesNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Cleonardo A da SilvaNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Paulo P de AssumpçãoNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Ândrea K C Ribeiro-Dos-SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Sidney E B Dos SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.
Marianne R FernandesNúcleo de Pesquisa em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, Belém, 66073-000 Brazil.
Ney P C Dos SantosLaboratório de Genética Humana e Médica, Universidade Federal do Pará, Rua Augusto Corrêa, N° 1, Belém, PA 66075-110 Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tuberculosis (TB) is an infectious disease caused by the bacterium Methods: This case-control study enrolled 283 individuals with active tuberculosis and 145 health care workers. Four INDELs and 13 single nucleotide polymorphisms and were genotyped using Multiplex PCR method and TaqMan SNP Genotyping Assays. Group comparisons for categorical variables were performed using the chi-squared test, whilst the t-Student test was used to analyze the continuous variables. Multiple logistic regression analyses were performed to estimate the odds ratio (OR) with 95% confidence intervals (CI). Deviation from Hardy-Weinberg equilibrium was assessed using chi-squared tests with Bonferroni correction. The results were analyzed comparing the genotypic distributions adopting the dominant model and the estimated values ​​of Results: The HWE test confirmed that the genotypic frequencies for polymorphisms were balanced. The frequency of Del allele was 73 and 75%, in cases and controls respectively. Frequency of Del allele was significantly higher in the control group than TB group. The homozygous Del/Del genotype was present in 51.6% of cases and 58.6% of controls. The rare Ins/Ins genotype was present in only 7.6% of controls and 6% of cases. The Conclusions: The Del/Del genotype of the rs4646994 in

Indexed as

ACEINDELPolymorphismsSusceptibilityTuberculosis

Identifiers

PMID35571459
PMCPMC9092330

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.