Evidence map›Paper›PMID 35571369›Full record

ReviewFrontiers in molecular neuroscience2022

Altered Mitochondrial Protein Homeostasis and Proteinopathies.

Aya Jishi, Xin Qi

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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  13. Mitochondria inter-organelle relationships in cancer protein aggregation.Frontiers in cell and developmental biology · 2022
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Aya JishiDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Xin QiDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, United States.
Case Western Reserve University · USUniversity School · US

Funding

Mechanism of white matter pathology in Alzheimer's diseaseR01AG076051 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIN QI · 2022 to 2026
$3.0M
Role of brain lipid metabolism in Alzheimer's diseaseR01AG065240 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2020 to 2024
$3.0M
Proteostasis dysregulation and alpha-synucleinR01NS115903 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2020 to 2023
$2.4M
Regulation of CHCHD6 in Alzheimer's diseaseRF1AG074346 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2022 to 2022
$2.1M
Mitochondrial biomarkers in Huntington's diseaseR21NS107897 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2019 to 2019
$453k
NIA NIH HHS R01 AG065240NIA NIH HHS R01 AG076051NIA NIH HHS RF1 AG074346NINDS NIH HHS R01 NS115903NINDS NIH HHS R21 NS107897
6 · The paper itself

Abstract

Increasing evidence implicates mitochondrial dysfunction as key in the development and progression of various forms of neurodegeneration. The multitude of functions carried out by mitochondria necessitates a tight regulation of protein import, dynamics, and turnover; this regulation is achieved

Indexed as

mitochondrial dysfunctionmitochondrial quality controlneurodegenerationprotein homeostasisproteinopathies

Identifiers

PMID35571369
PMCPMC9095842
OpenAlexW4224928165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.