ArticleFrontiers in behavioral neuroscience2022
The Foot Fault Scoring System to Assess Skilled Walking in Rodents: A Reliability Study.
Article in Frontiers in behavioral neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Maternal Infection Impairs Motor Coordination in an Experimental Meningitis Rat Model Through Altered MMP-2/3/9 Activity, H3K4 Trimethylation, andInternational journal of molecular sciences · 2026Article
- Bone marrow mesenchymal stem cells ameliorate intermittent multiple sclerosis: quantitative cerebellar microscopy and functional analysis in cuprizone-induced mice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Establishing an experimental model approach to thermal-induced spinal cord injury in mice.Frontiers in cellular neuroscience · 2026Article
- Short- and Long-Term Effects of Sodium Phenylbutyrate on White Matter and Sensorimotor and Cognitive Behavior in a Mild Murine Model of Encephalopathy of Prematurity.International journal of molecular sciences · 2025Article
- Exposure to an enriched environment modulates the synaptic vesicle cycle in a mouse spinal cord injury model.Scientific reports · 2024Article
- Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats.Molecular and cellular biochemistry · 2023Article
- Can anxiety-like behavior and spatial memory predict the extremes of skilled walking performance in mice? An exploratory, preliminary study.Frontiers in behavioral neuroscience · 2023Article
- Intermediate gray matter interneurons in the lumbar spinal cord play a critical and necessary role in coordinated locomotion.PloS one · 2023Article
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4 authors.
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Abstract
The foot fault scoring system of the ladder rung walking test (LRWT) is used to assess skilled walking in rodents. However, the reliability of the LRWT foot fault score has not been properly addressed. This study was designed to address this issue. Two independent and blinded raters analyzed 20 rats and 20 mice videos. Each video was analyzed twice by the same rater (80 analyses per rater). The intraclass correlation coefficient (ICC) and the Kappa coefficient were employed to check the accuracy of agreement and reliability in the intra- and inter-rater analyses of the LRWT outcomes. Excellent intra- and inter-rater agreements were found for the forelimb, hindlimb, and both limbs combined in rats and mice. The agreement level was also excellent for total crossing time, total time stopped, and the number of stops during the walking path. Rating individual scores in the foot fault score system (0-6) ranged from satisfactory to excellent, in terms of the intraclass correlation indexes. Moreover, we showed that experienced and inexperienced raters can obtain reliable results if supervised training is provided. We concluded that the LRWT is a reliable and useful tool to study skilled walking in rodents and can help researchers address walking-related neurobiological questions.
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