Evidence map›Paper›PMID 35571249›Full record

ArticleOxidative medicine and cellular longevity2022

Endogenous Hydrogen Sulfide Persulfidates Caspase-3 at Cysteine 163 to Inhibit Doxorubicin-Induced Cardiomyocyte Apoptosis.

Xiaoyun Ye, Yingying Li, Boyang Lv, Bingquan Qiu, Shangyue Zhang, Hanlin Peng, Wei Kong, Chaoshu Tang, Yaqian Huang, Junbao Du and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  4. Molecular mechanisms and intervention approaches of heart failure (Review).International journal of molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xiaoyun YeDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Yingying LiDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Boyang LvDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Bingquan QiuDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Shangyue ZhangDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Hanlin PengDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Wei KongDepartment of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
Chaoshu TangDepartment of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China.
Yaqian HuangDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Junbao DuDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Hongfang JinDepartment of Pediatrics, Peking University First Hospital, Beijing 100034, China.ORCID https://orcid.org/0000-0002-1606-8988
Peking University · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Doxorubicin (DOX) is an efficient antitumor anthracycline drug, but its cardiotoxicity adversely affects the prognosis of the patients. In this study, we explored whether endogenous gasotransmitter hydrogen sulfide (H

Indexed as

Antineoplastic AgentsHydrogen SulfideApoptosisCaspase 3Cystathionine gamma-LyaseCysteineDoxorubicinHumansMyocytes, CardiacAntineoplastic AgentsCaspase 3Cystathionine gamma-LyaseCysteineDoxorubicinHydrogen Sulfide

Identifiers

PMID35571249
PMCPMC9095366
OpenAlexW4229036033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.