Evidence map›Paper›PMID 35571097›Full record

ArticleFrontiers in pharmacology2022

Dual Blockade of Misfolded Alpha-Sarcoglycan Degradation by Bortezomib and Givinostat Combination.

Lucile Hoch, Nathalie Bourg, Fanny Degrugillier, Céline Bruge, Manon Benabides, Emilie Pellier, Johana Tournois, Gurvan Mahé, Nicolas Maignan, Jack Dawe and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. On RNA-programmable gene modulation as a versatile set of principles targeting muscular dystrophies.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Lucile HochCECS, I-Stem, Corbeil-Essonne, France.
Nathalie BourgINTEGRARE, Genethon, Inserm, Univ Evry, Université Paris-Saclay, Evry, France.
Fanny DegrugillierUniversité Paris Est Creteil, INSERM, IMRB, Créteil, France.
Céline BrugeCECS, I-Stem, Corbeil-Essonne, France.
Manon BenabidesCECS, I-Stem, Corbeil-Essonne, France.
Emilie PellierCECS, I-Stem, Corbeil-Essonne, France.
Johana TournoisCECS, I-Stem, Corbeil-Essonne, France.
Gurvan MahéCECS, I-Stem, Corbeil-Essonne, France.
Nicolas MaignanKANTIFY, Bruxelles, Belgium.
Jack DaweKANTIFY, Bruxelles, Belgium.
Maxime GeorgesKANTIFY, Bruxelles, Belgium.
David PapazianKANTIFY, Bruxelles, Belgium.
Nik SubramanianKANTIFY, Bruxelles, Belgium.
Stéphanie SimonUniversité Paris Est Creteil, INSERM, IMRB, Créteil, France.
Pascale FanenUniversité Paris Est Creteil, INSERM, IMRB, Créteil, France.
Cédric DelevoyeInstitut Curie, PSL Research University, CNRS, UMR144, Structure and Membrane Compartments, Paris, France.
Isabelle RichardINTEGRARE, Genethon, Inserm, Univ Evry, Université Paris-Saclay, Evry, France.
Xavier NissanCECS, I-Stem, Corbeil-Essonne, France.
Inserm · FRLeefmilieu Brussel · BECentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limb-girdle muscular dystrophy type R3 (LGMD R3) is a rare genetic disorder characterized by a progressive proximal muscle weakness and caused by mutations in the

Indexed as

autophagydrug repurposinggivinostatHDAC inhibitormisfolded protein

Identifiers

PMID35571097
PMCPMC9093689
OpenAlexW4285741616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.