Evidence map›Paper›PMID 35571034›Full record

ArticleFrontiers in genetics2022

Genome Instability-Associated Long Non-Coding RNAs Reveal Biomarkers for Glioma Immunotherapy and Prognosis.

Xinzhuang Wang, Hong Zhang, Junyi Ye, Ming Gao, Qiuyi Jiang, Tingting Zhao, Shengtao Wang, Wenbin Mao, Kaili Wang, Qi Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinzhuang WangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hong ZhangDepartment of Hematology, Liaocheng People's Hospital, Liaocheng, China.
Junyi YeDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ming GaoDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Qiuyi JiangDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Tingting ZhaoBiochip Laboratory, Yantai Yu-Huang-Ding Hospital, Qingdao University, Yantai, China.
Shengtao WangThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Wenbin MaoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Kaili WangThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Qi WangThe First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xin ChenDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Xu HouDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Dayong HanDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome instability is a hallmark of tumors and is involved in proliferation, invasion, migration, and treatment resistance of many tumors. However, the relationship of genome instability with gliomas remains unclear. Here, we constructed genome instability-derived long non-coding RNA (lncRNA)-based gene signatures (GILncSig) using genome instability-related lncRNAs derived from somatic mutations. Multiple platforms were used to confirm that the GILncSig were closely related to patient prognosis and clinical characteristics. We found that GILncSig, the glioma microenvironment, and glioma cell DNA methylation-based stemness index (mDNAsi) interacted with each other to form a complex regulatory network. In summary, this study confirmed that GILncSig was an independent prognostic indicator for patients, distinguished high-risk and low-risk groups, and affected immune-cell infiltration and tumor-cell stemness indicators (mDNAsi) in the tumor microenvironment, resulting in tumor heterogeneity and immunotherapy resistance. GILncSig are expected to provide new molecular targets for the clinical treatment of patients with gliomas.

Indexed as

genome instabilitygliomalncRNAMDNAsiTCGAtumor microenvironment

Identifiers

PMID35571034
PMCPMC9094631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.