ArticleFrontiers in genetics2022
Prenatal Exposure to a Climate-Related Disaster Results in Changes of the Placental Transcriptome and Infant Temperament.
Article in Frontiers in genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Racial Disparities in Nulliparous Singleton Term Vertex Cesarean Deliveries: Rates, Reasons, and Time to Delivery.Birth (Berkeley, Calif.) · 2025Article
- The Impact of Climate Change and Environmental Stressors on Maternal Mental Health: A Narrative Review.Cureus · 2025Review
- Seasonal Influences on Human Placental Transcriptomes Associated with Spontaneous Preterm Birth.Cells · 2025Article
- Prenatal Maternal Mindfulness as a Predictor of Infant Emerging Effortful Control and Negative Affect.Mindfulness · 2025Article
- Behavioral moderators ofFrontiers in psychiatry · 2025Article
- Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Controlling fetal stress for preventing adverse health conditions in neonates and children.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Maternal stress during pregnancy exerts long-term effects on the mental well-being of the offspring. However, the long-term effect of prenatal exposure on the offspring's mental status is only partially understood. The placenta plays a vital role in connecting the maternal side to the fetus, thereby serving as an important interface between maternal exposure and fetal development. Here, we profiled the placental transcriptome of women who were pregnant during a hurricane (Superstorm Sandy), which struck New York City in 2012. The offspring were followed longitudinally and their temperament was assessed during the first 6-12 months of age. The data identified a significant correlation between a Superstorm Sandy stress factor score and infant temperament. Further, analysis of the placental transcriptomes identified an enrichment of functional pathways related to inflammation, extracellular matrix integrity and sensory perception in the specimen from those infants with "Slow-to-Warm-up" temperament during the first year of life. Together, these findings provide initial evidence that maternal exposure to climate-related disasters results in altered placental transcriptome, which may be related to long-term emotional and behavioral consequences in children.
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Registered trials
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