Evidence map›Paper›PMID 35570994›Full record

ArticleKidney international reports2022

Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort.

Doris Winitzki, Helena U Zacharias, Jennifer Nadal, Seema Baid-Agrawal, Elke Schaeffner, Matthias Schmid, Martin Busch, Manuela M Bergmann, Ulla Schultheiss, Fruzsina Kotsis and 10 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 2 countries.

Doris WinitzkiDivision of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Helena U ZachariasDepartment of Internal Medicine I, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Jennifer NadalInstitute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
Seema Baid-AgrawalSahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.
Elke SchaeffnerInstitute of Public Health, Charité -Universitätsmedizin Berlin, Berlin, Germany.
Matthias SchmidInstitute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
Martin BuschDepartment of Internal Medicine III, University Hospital Jena, Jena, Germany.
Manuela M BergmannGerman Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.
Ulla SchultheissInstitute of Genetic Epidemiology, University of Freiburg Faculty of Medicine, Freiburg, Germany.
Fruzsina KotsisInstitute of Genetic Epidemiology, University of Freiburg Faculty of Medicine, Freiburg, Germany.
Helena StockmannDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Heike MeiselbachDepartment of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.
Gunter WolfDepartment of Internal Medicine III, University Hospital Jena, Jena, Germany.
Vera KraneDepartment of Medicine I, Division of Nephrology, University Hospital Würzburg, Würzburg, Germany.
Claudia SommererDepartment of Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Markus P SchneiderDepartment of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.
Georg SchlieperDivision of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Jürgen FloegeDivision of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Turgay SaritasDivision of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Charité - Universitätsmedizin Berlin · DERWTH Aachen University · DEJena University Hospital · DEUniversity of Freiburg · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Institute of Human Nutrition · DEKiel University · DEKrankenhaus der Augustinerinnen · DENuremberg Hospital · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Bonn · DEUniversity Hospital Heidelberg · DEUniversity of Gothenburg · SEZimmer Biomet (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology. Methods: Participants ( Results: Participants with low educational attainment (vs. high) had a higher risk for mortality (hazard ratio [HR] 1.48, 95% CI: 1.16-1.90), MACE (HR 1.37, 95% CI: 1.02-1.83), and kidney failure (HR 1.54, 95% CI: 1.15-2.05). Mediators between low educational attainment and mortality were smoking, CV disease (CVD) at baseline, low income, higher body mass index, and higher serum levels of CRP, high-density lipoprotein cholesterol, uric acid, NGAL, BAP, NT-proBNP, OPN, H-FABP, and urea. Low educational attainment was positively associated with diabetic nephropathy (odds ratio [OR] 1.65, 95% CI: 1.36-2.0) and CKD subsequent to acute kidney injury (OR 1.56, 95% CI: 1.03-2.35), but negatively associated with IgA nephropathy (OR 0.68, 95% CI: 0.52-0.90). Conclusion: Low educational attainment is associated with adverse outcomes and CKD etiology. Lifestyle habits and biomarkers mediate associations between low educational attainment and mortality. Recognition of the role of educational attainment and the associated health-relevant risk factors is important to optimize the care of patients with CKD and improve prognosis.

Indexed as

biomarkerCASMINchronic kidney diseaseCKDeducational attainmentsocioeconomic status

Identifiers

PMID35570994
PMCPMC9091575
OpenAlexW4213028269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.