ArticleRestorative neurology and neuroscience2022
Efficacy of mechanisms of neuroplasticity after a stroke.
Article in Restorative neurology and neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Backward Walking as a Rehabilitation Strategy in Parkinson's Disease: A Focused Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Efficacy of Motor Imagery in the Treatment of Poststroke Dysphagia: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Pooled it
- Theta burst stimulation: what role does it play in stroke rehabilitation? A systematic review of the existing evidence.BMC neurology · 2024Pooled it
- The effectiveness of intermittent theta burst stimulation for upper limb motor recovery after stroke: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neuroscience · 2023Pooled it
- Upper-Limb Motor Recovery in the Late Subacute Phase After Stroke: A Single-Case Experimental Study of Robot-Assisted Therapy, rTMS, and Intensive Training for Upper-Limb Rehabilitation in the First Year After Stroke Using Modern Treatment Strategies.Journal of clinical medicine · 2026Article
- Unveiling the Clinical Impact of Lower Limb Robotic Devices in Neurorehabilitation: An Umbrella Review.Annals of biomedical engineering · 2026Review
- A protocol to optimize non-invasive brain stimulation for post-stroke rehabilitation.MethodsX · 2025Article
- Determinants of exercise adherence in sedentary middle-aged and older adults.Psychophysiology · 2024Article
- A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses.Biomedicines · 2024Article
- Design and analysis of a compatible exoskeleton rehabilitation robot system based on upper limb movement mechanism.Medical & biological engineering & computing · 2024Article
- Exploring the transformative influence of neuroplasticity on stroke rehabilitation: a narrative review of current evidence.Annals of medicine and surgery (2012) · 2023Review
- Prefrontal activation in response to a plantar contact task under open and closed eye conditions in patients with cerebral infarction.Frontiers in neuroscience · 2023Article
- Virtual reality-induced motor function of the upper extremity and brain activation in stroke: study protocol for a randomized controlled trial.Frontiers in neurology · 2023Article
- A review of the impact of circadian rhythm on motor function in stroke recovery patients.Frontiers in neurologyReview
- Repetitive transcranial magnetic stimulation for post stroke rehabilitation-a single center community experience.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe sequelae of stoke, including the loss and recovery of function, are strongly linked to the mechanisms of neuroplasticity. Rehabilitation and non-invasive brain stimulation (NIBS) paradigms have shown promise in modulating corticomotor neuroplasticity to promote functional recovery in individuals post-stroke. However, an important limitation to these approaches is that while stroke recovery depends on the mechanisms of neuroplasticity, those mechanisms may themselves be altered by a stroke.
objectiveCompare Transcranial Magnetic Stimulation (TMS)-based assessments of efficacy of mechanism of neuroplasticity between individuals post-stroke and age-matched controls.
methodsThirty-two participants (16 post-stroke, 16 control) underwent an assessment of mechanisms of neuroplasticity, measured by the change in amplitude of motor evoked potentials elicited by single-pulse TMS 10-20 minutes following intermittent theta-burst stimulation (iTBS), and dual-task effect (DTE) reflecting cognitive-motor interference (CMI). In stroke participants, we further collected: time since stroke, stroke type, location, and Stroke Impact Scale 16 (SIS-16).
resultsAlthough there was no between-group difference in the efficacy of TMS-iTBS neuroplasticity mechanism (p = 0.61, η2 = 0.01), the stroke group did not exhibit the expected facilitation to TMS-iTBS (p = 0.60, η2 = 0.04) that was shown in the control group (p = 0.016, η2 = 0.18). Sub-cohort analysis showed a trend toward a difference between those in the late-stage post-stroke and the control group (p = 0.07, η2 = 0.12). Within the post-stroke group, we found significant relationships between TMS-iTBS neuroplasticity and time since stroke onset, physical function (SIS-16), and CMI (all rs > |0.53| and p-values < 0.05).
conclusionsIn this proof-of-principle study, our findings suggested altered mechanisms of neuroplasticity in post-stroke patients which were dependent on time since stroke and related to motor function. TMS-iTBS neuroplasticity assessment and its relationship with clinical functional measures suggest that TMS may be a useful tool to study post-stroke recovery. Due to insufficient statistical power and high variability of the data, generalization of the findings will require replication of the results in a larger, better-characterized cohort.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.