ArticleJournal of Alzheimer's disease : JAD2022
Pre-Diagnostic Symptoms of Young-Onset Dementia in the General Practice up to Five Years Before Diagnosis.
Article in Journal of Alzheimer's disease : JAD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Comparison of pre-diagnostic signs and symptoms of young-onset dementia and late-onset dementia in the general practice.Journal of Alzheimer's disease : JAD · 2026Article
- The prevalence and incidence of young onset dementia in the Netherlands: a prospective study in two catchment areas.Alzheimer's research & therapy · 2026Article
- Neurology-Related Research Using the German Disease Analyzer Database: A Narrative Review of Studies Published Between 2020 and 2025.NeuroSci · 2026Review
- Mental health symptoms as preclinical indicators of dementia: a Whitehall II cohort study.medRxiv : the preprint server for health sciences · 2026Article
- Real-world prediction of early-onset dementia by health record data: A multi-center machine learning study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Everyday functioning in young onset dementia: differences between diagnostic groups.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- 'Too young to sit at home': a qualitative study conducted among employees with young-onset dementia and their relatives.Aging & mental health · 2024Article
- Post-diagnostic support for persons with young-onset dementia - a retrospective analysis based on data from the Swedish dementia registry SveDem.BMC health services research · 2024Article
- Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Dementia in People with Severe/Profound Intellectual (And Multiple) Disabilities, and Its Natural History.Journal of mental health research in intellectual disabilities · 2024Article
- A Perspective: Challenges in Dementia Research.Medicina (Kaunas, Lithuania) · 2022Article
- Young-onset dementia in memory clinics in the Netherlands: Study design and description of PRECODE-GP.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
11 authors.
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Abstract
backgroundYoung-onset dementia (YOD) has many underlying etiologies, leading to a large heterogeneity in first symptoms. This makes it difficult for general practitioners (GPs) to recognize YOD.
objectiveIdentify early symptoms that are more common in the pre-diagnostic phase of YOD.
methodsWe performed a case-control study nested in a primary-care registry on 89 cases and 162 matched controls, where we compared symptoms of people with YOD up to 5 years before diagnosis to their matched control group without YOD. The variables included in this study were International Classification of Primary Care codes and symptoms extracted from written GP notes and categorized in groups. We used Generalized Equation Estimation to analyze symptom's time-trajectories and logistic regression and ROC-curves to analyze differences in number of symptom categories reported.
resultsCognitive symptoms were more common in people with YOD 5 years before diagnosis, affective symptoms 4 years before diagnosis, social symptoms 3 years, behavioral symptoms 2 years, and daily functioning disturbances 1 year before diagnosis. The ROC-curve suggested that reporting two or more symptom categories at the GP gave the best trade-off between sensitivity (85%) and specificity (77%), for the highest percentage of correctly diagnosed persons.
conclusionThis study showed people with YOD present differently than people without YOD. However, it may still be difficult for GPs to use these symptom categories to distinguish people with YOD, since the symptoms also occur in people with other diseases. A combination of reported symptom categories increases the probability of an underlying cause of YOD.
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