Evidence map›Paper›PMID 35570362›Full record

ArticleEuropean eating disorders review : the journal of the Eating Disorders Association2022

Examining the relationship between autistic spectrum disorder characteristics and structural brain differences seen in anorexia nervosa.

Daniel Halls, Jenni Leppanen, Jess Kerr-Gaffney, Mima Simic, Dasha Nicholls, William Mandy, Steven Williams, Kate Tchanturia

Abstract read
In one paragraph

Article in European eating disorders review : the journal of the Eating Disorders Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Cortical complexity in eating disorders: a systematic review and qualitative synthesis.European archives of psychiatry and clinical neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniel HallsKing's College London (KCL), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, London, UK.ORCID 0000-0002-5372-3179
Jenni LeppanenKing's College London, Centre for Neuroimaging Sciences, London, UK.ORCID 0000-0003-2814-4375
Jess Kerr-GaffneyKing's College London (KCL), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, London, UK.ORCID 0000-0001-5834-8307
Mima SimicSouth London and Maudsley NHS Foundation Trust, London, UK.
Dasha NichollsDivision of Psychiatry, Imperial College London, London, UK.
William MandyDivision of Psychology and Language Sciences, University College London, London, UK.ORCID 0000-0002-3564-5808
Steven WilliamsKing's College London, Centre for Neuroimaging Sciences, London, UK.
Kate TchanturiaKing's College London (KCL), Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Psychological Medicine, London, UK.ORCID 0000-0001-8988-3265

Funding

Medical Research Council MR/S020381/1MRF_ MRF-058-0012-RG-TCHA-C0762
6 · The paper itself

Abstract

Cortical differences have been reported in Anorexia Nervosa (AN) compared with healthy controls (HC); however, it is unclear if Autism Spectrum Disorder (ASD) characteristics are related to these cortical differences. The aim of this study was to examine if structural measures were correlated to ASD traits in AN. In total 184 female participants participated in the study; 57 acutely underweight AN participants (AAN), 59 weight-restored participants (WR) and 68 HC. Participants underwent structural magnetic resonance imaging as well as completing the Autism Diagnostic Observation schedule, second edition to examine ASD characteristics. Group differences in curvature, gyrification, surface area, thickness, global grey matter and white matter were measured. Correlation and regression analysis were conducted to examine the relationship between cortical measures and ASD characteristics. Two decreased gyrification clusters in the right post central and supramarginal gyrus and decreased global grey matter were observed in the AAN group compared to HC and WR. No correlations between ASD traits and structural measures existed. Our results suggest structural differences seen in individuals with AN do not appear to be related to ASD characteristics.

Indexed as

Anorexia NervosaAutism Spectrum DisorderWhite MatterBrainFemaleHumansMagnetic Resonance Imaginganorexia nervosaautism spectrum disordergyrificationstructural MRIsurfaced-based morphometry

Identifiers

PMID35570362
PMCPMC9546313

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.