Evidence map›Paper›PMID 35570331›Full record

ArticleCPT: pharmacometrics & systems pharmacology2022

Flexible and efficient Bayesian pharmacometrics modeling using Stan and Torsten, Part I.

Charles C Margossian, Yi Zhang, William R Gillespie

Abstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Bayesian Workflow for Minimal PBPK Models: Case Study of Dapagliflozin.CPT: pharmacometrics & systems pharmacology · 2026
    Article
  2. Article
  3. Pharmacometric modeling with the zero-order hold.Journal of pharmacokinetics and pharmacodynamics · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Bayesian Calibration to Address the Challenge of Antimicrobial Resistance: A Review.IEEE access : practical innovations, open solutions · 2024
    Article
  9. Article
  10. Bayesian PBPK modeling using R/Stan/Torsten and Julia/SciML/Turing.Jl.CPT: pharmacometrics & systems pharmacology · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Charles C MargossianDepartment of Statistics, Columbia University (formerly Metrum Research Group, Inc.), New York, New York, USA.
Yi ZhangMetrum Research Group, Inc., Tariffville, Connecticut, USA.
William R GillespieMetrum Research Group, Inc., Tariffville, Connecticut, USA.ORCID 0000-0002-4560-6482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stan is an open-source probabilistic programing language, primarily designed to do Bayesian data analysis. Its main inference algorithm is an adaptive Hamiltonian Monte Carlo sampler, supported by state-of-the-art gradient computation. Stan's strengths include efficient computation, an expressive language that offers a great deal of flexibility, and numerous diagnostics that allow modelers to check whether the inference is reliable. Torsten extends Stan with a suite of functions that facilitate the specification of pharmacokinetic and pharmacodynamic models and makes it straightforward to specify a clinical event schedule. Part I of this tutorial demonstrates how to build, fit, and criticize standard pharmacokinetic and pharmacodynamic models using Stan and Torsten.

Indexed as

AlgorithmsBayes TheoremHumansMonte Carlo Method

Identifiers

PMID35570331
PMCPMC9469701

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.