Evidence map›Paper›PMID 35570012›Full record

ArticleInternational dental journal2022

Ion Concentration of Silver Diamine Fluoride Solutions.

Iliana Gehui Yan, Faith Miaomiao Zheng, Sherry Shiqian Gao, Duangporn Duangthip, Edward Chin Man Lo, Chun Hung Chu

Open access · goldAbstract read
In one paragraph

Article in International dental journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Silver diamine fluoride for non-operative restorative treatment and prevention of dental caries.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Iliana Gehui YanFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Faith Miaomiao ZhengFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Sherry Shiqian GaoSchool of Medicine, Xiamen University, Xiamen, China.
Duangporn DuangthipFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Edward Chin Man LoFaculty of Dentistry, The University of Hong Kong, Hong Kong, China.
Chun Hung ChuFaculty of Dentistry, The University of Hong Kong, Hong Kong, China. Electronic address: chchu@hku.hk.
University of Hong Kong · HKXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this work was to determine the free fluoride and silver ion concentrations and the alkalinity of 4 commercially available 38% silver diamine fluoride (SDF) solutions.

methodsFour common brands of 38% SDF solutions, namely Saforide, Advantage Arrest, e-SDF, and Topamine, were selected. Three bottles of each brand of SDF solution from the same lot were assessed. Measurements of the silver and fluoride content and alkalinity were performed directly when a bottle was opened. Each measurement was repeated to recheck its reliability. The free fluoride ion concentrations were measured using a calibrated ion-selective electrode. The free silver ion concentrations were measured using optical emission spectrometry. The alkalinity of the SDF solution was determined with a pH electrode.

resultsThe mean concentrations of fluoride ions of the Saforide, Advantage Arrest, e-SDF, and Topamine were 43,233 ppm, 44,333 ppm, 51,370 ppm, and 54,400 ppm, respectively; their percentage differences from the expected value (44,800 ppm) were 3.5%, 2.4%, 14.7%, and 21.4%, respectively. The mean concentrations of silver ions of the Saforide, Advantage Arrest, e-SDF, and Topamine were 258,841 ppm, 260,016 ppm, 336,149 ppm, and 319,966 ppm, respectively; their percentage differences from the expected value (253,900 ppm) were 3.2%, 5.8%, 32.4%, and 25.9%, respectively. The 4 products had pH values of 9.2, 9.1, 9.2, and 9.0, respectively.

conclusionsThis study showed differences between the claimed and measured fluoride and silver ion concentrations in 4 common 38% SDF products, which were alkaline with a pH value of 9.

Indexed as

Cariostatic AgentsDental CariesFluoridesFluorides, TopicalHumansQuaternary Ammonium CompoundsReproducibility of ResultsSilver CompoundsSodium FluorideCariostatic AgentsFluoridesFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideSodium FluorideCariesChildrenPreventionSilver diamine fluorideSodium fluorideTopical fluoride

Identifiers

PMID35570012
PMCPMC9676425
OpenAlexW4280492498

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.