Evidence map›Paper›PMID 35569252›Full record

ArticleInternational journal of hygiene and environmental health2022

Polybrominated diphenyl ethers in early pregnancy and preterm birth: Findings from the NICHD Fetal Growth Studies.

Zifan Wang, Cuilin Zhang, Paige L Williams, Andrea Bellavia, Blair J Wylie, Michele R Hacker, Kurunthachalam Kannan, Michael S Bloom, Kelly J Hunt, Russ Hauser and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Polybrominated diphenyl ethers and gestational weight gain: a multi-center prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2024
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Zifan WangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: zifanwang@g.harvard.edu.
Cuilin ZhangDivision of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Paige L WilliamsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Andrea BellaviaDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Blair J WylieDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, USA.
Michele R HackerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, USA.
Kurunthachalam KannanDepartment of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.
Michael S BloomDepartment of Global and Community Health, George Mason University, Fairfax, VA, USA.
Kelly J HuntDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Russ HauserDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tamarra James-ToddDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USBeth Israel Deaconess Medical Center · USGeorge Mason University · USMedical University of South Carolina · USNational Institutes of Health · USNew York University · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Exposome Contributors to Child Health Originating from National Fetal Growth Study (ECCHO-NFGS)UG3OD023316 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HUNT, KELLY J, WAPNER, RONALD · 2016 to 2017
$10.8M
Maternal organophosphate pesticide exposure, low birth weight and placental injuryR01ES028688 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HACKER, MICHELE RENEE, WYLIE, BLAIR JOHNSON · 2018 to 2021
$2.1M
NICHD NIH HHS HHSN275200800002CNICHD NIH HHS HHSN275200800002INICHD NIH HHS HHSN275200800003CNICHD NIH HHS HHSN275200800003INICHD NIH HHS HHSN275200800012CNICHD NIH HHS HHSN275200800013CNICHD NIH HHS HHSN275200800014CNICHD NIH HHS HHSN275200800028CNICHD NIH HHS HHSN275200800031CNICHD NIH HHS HHSN275201000001GNICHD NIH HHS HHSN275201000001ZNICHD NIH HHS HHSN275201000009CNIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES028688NIH HHS UG3 OD023316
6 · The paper itself

Abstract

backgroundStudies suggest associations between exposure to individual polybrominated diphenyl ethers (PBDEs) with preterm birth (PTB) and shorter gestational age. Little is known about exposure to PBDE mixtures and these outcomes. We evaluated associations of multiple PBDEs in early pregnancy with gestational age at delivery and PTB.

methodsData were collected from 2046 women without obesity and 396 women with obesity from the NICHD Fetal Growth Studies, who had early pregnancy plasma PBDEs concentrations and gestational age at delivery. PTB was defined as < 37 weeks of gestation at delivery and further categorized into subtypes (late or very early/moderate; spontaneous or medically indicated). We applied (1) generalized linear models (GLM); (2) principal component analysis (PCA); and (3) Bayesian Kernel Machine Regression (BKMR) to evaluate the individual and joint associations of log-transformed PBDE concentrations with gestational age at delivery and PTB, adjusting for potential confounders and evaluating effect modifiers.

resultsIn GLM analyses, a 1-standard deviation (SD) increase in log-PBDE 153 was associated with shorter gestational age at delivery [adjusted β (95% CI) = -0.19 (-0.31, -0.06) weeks] among women without obesity. In PCA analyses, 1-SD increase in the principal component summarizing most of PBDE 153 variability was associated with shorter gestational age at delivery [adjusted β (95% CI) = -0.18 (-0.30, -0.06) weeks], very early/moderate PTB [adjusted OR (95% CI) = 1.91 (1.19, 3.07)], and spontaneous PTB [adjusted OR (95% CI) = 1.34 (1.00, 1.80)] among women without obesity. Associations were stronger among non-Hispanic Black women, women with BMI ranging between 25 and 30 kg/m

conclusionsPBDEs, specifically PBDE 153, were associated with shorter gestation and higher risk of certain PTB subtypes among pregnant women without obesity.

Indexed as

Environmental PollutantsPremature BirthAdultBayes TheoremFemaleFetal DevelopmentHalogenated Diphenyl EthersHumansInfant, NewbornMaternal ExposureNational Institute of Child Health and Human Development (U.S.)ObesityPregnancyUnited StatesEnvironmental PollutantsHalogenated Diphenyl EthersEnvironmental mixturesGestational agePolybrominated diphenyl ethersPreterm birth

Identifiers

PMID35569252
PMCPMC9302707
OpenAlexW4280501771

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.