ArticleThe Journal of physiology2022
Slowly-adapting type II afferents contribute to conscious touch sensation in humans: Evidence from single unit intraneural microstimulation.
Article in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- A methodological framework for the efficient characterization of peripheral nerve stimulation parameters.Journal of neural engineering · 2025Trial
- A lasting impression.eLife · 2025Article
- Fingertip viscoelasticity enables human tactile neurons to encode loading history alongside current force.eLife · 2025Article
- Local postural changes elicit extensive and diverse skin stretch around joints, on the trunk and the face.Journal of the Royal Society, Interface · 2025Article
- A neurocognitive pathway for engineering artificial touch.Science advances · 2024Review
- Proprioceptors of the human pericardium.Basic research in cardiology · 2024Article
- Precise tactile localization on the human fingernail.Proceedings. Biological sciences · 2024Article
- How Tactile Afferents in the Human Fingerpad Encode Tangential Torques Associated with Manipulation: Are Monkeys Better than Us?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Population coding strategies in human tactile afferents.PLoS computational biology · 2022Article
- Peripheral neurostimulation for encoding artificial somatosensations.The European journal of neuroscience · 2022Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
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Abstract
Slowly-adapting type II (SA-II, Ruffini) mechanoreceptive afferents respond well to pressure and stretch, and are regularly encountered in human microneurography studies. Despite an understanding of SA-II response properties, their role in touch perception remains unclear. Specific roles of different myelinated Aβ mechanoreceptive afferents in tactile perception have been revealed using single unit intraneural microstimulation (INMS), via microneurography, recording from and then electrically stimulating individual afferents. This method directly links single afferent artificial activation to perception, where INMS produces specific 'quantal' touch percepts associated with different mechanoreceptive afferent types. However, SA-II afferent stimulation has been ambiguous, producing inconsistent, vague sensations, or no clear percept. We physiologically characterized hundreds of individual Aβ mechanoreceptive afferents in the glabrous hand skin and examined the subsequent percepts evoked by trains of low amplitude INMS current pulses (<10 μA). We present 18 SA-II afferents where INMS resulted in a clear, electrically evoked sensation of large (∼36 mm
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.