ArticleBMC musculoskeletal disorders2022
Evaluation of the efficacy of platelet rich fibrin (I-PRF) intra-articular injections in the management of internal derangements of temporomandibular joints - a controlled preliminary prospective clinical study.
Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparative Study Between Botulinum Toxin Versus Platelet Rich Fibrin Injection for Treatment of Temporomandibular Joint Internal Derangement
Clinical and Radiographic Evaluation of the Efficacy of Injectable PRF(Platelet-rich Fibrin ) in Management of Temporomandibular Joint Internal Derangement: a Randomised Controlled Clinical Study
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Comparative efficacy of arthrocentesis combined with different drug injections for arthrogenic temporomandibular disorders: a network meta-analysis of randomized trials.BMC oral health · 2026Pooled it
- Advanced, pharmacological and complementary interventions for chronic or recurrent orofacial pain conditions: a systematic evidence map with selective meta-analyses.The journal of headache and pain · 2026Pooled it
- Is injectable platelet rich fibrin beneficial in managing intracapsular temporomandibular disorders? A systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Effect of intraarticular drug injection in patients with temporomandibular joint disorders with limited mouth opening: a system review and network meta-analysis.Journal of oral & facial pain and headache · 2025Pooled it
- Er:YAG and Nd:YAG-based low-level laser therapy (LLLT) with medical collagen improve third-molar extraction wound healing: a randomized controlled trial.Lasers in medical science · 2025Trial
- The effect of collagen sponge placed in the socket after surgical extraction of mandibular third molars on the incidence of alveolar osteitis: a split mouth randomized controlled trial.Clinical oral investigations · 2025Trial
- Patient-Reported Quality of Life versus Physical Examination in Treating Temporomandibular Disorders with Intra-Articular Platelet-Rich Plasma Injections: An Open-Label Clinical Trial.International journal of environmental research and public health · 2022Trial
- A scoping review on platelet-rich fibrin-driven bone regeneration: biological mechanisms and clinical applications in oral and maxillofacial surgery.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026Article
- Baseline Oral Behaviours in Relation to Follow-Up Temporomandibular Joint Disease Severity After Intra-Articular I-PRF: A Baseline-Adjusted Exploratory Cohort Study.Journal of clinical medicine · 2026Article
- Article
- Dental publications on the treatment of temporomandibular disorders: A bibliometric analysis.F1000Research · 2026Review
- Autogenous Injections in Temporomandibular Disorders: A Systematic Review.Journal of clinical medicine · 2025Review
- A Comprehensive Analysis of the Efficacy of Injectable Medications in Relieving Temporomandibular Joint Discomfort: A Systematic Review.Journal of clinical practice and research · 2024Review
- Using platelet concentrates to treat maxillofacial tissue lesions.Frontiers in bioengineering and biotechnology · 2024Review
- Current Clinical Research Directions on Temporomandibular Joint Intra-Articular Injections: A Mapping Review.Journal of clinical medicine · 2023Review
- Platelet-Rich Plasma Power-Mix Gel (ppm)-An Orthobiologic Optimization Protocol Rich in Growth Factors and Fibrin.Gels (Basel, Switzerland) · 2023Review
- Injectable Platelet-Rich Fibrin (I-PRF) Administered to Temporomandibular Joint Cavities: A Scoping Review.Journal of clinical medicine · 2023Article
- Intra-Articular Injections into the Inferior versus Superior Compartment of the Temporomandibular Joint: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Repeated Intra-Articular Administration of Platelet-Rich Plasma (PRP) in Temporomandibular Disorders: A Clinical Case Series.Journal of clinical medicine · 2022Article
- Efficacy analysis of splint combined with platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis.Frontiers in pharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe temporomandibular joint (TMJ) is one of the most complex joints in the body. Temporomandibular disorders (TMD) are among the most troublesome disorders for patients, as they can cause pain, affect oral functions and disturb dentists on the level of diagnosis and treatment. The most common symptoms of temporomandibular joint disorders are articulated sounds (such as clicking or TMJ crepitation), joint pain in comfort and function situations (jaw movements), pain or strain in masseter and jaw muscles and or restricted mandibular movements. One of the most modern biocompatible substances used to treat joint disorders, including the TMJ, is platelet-rich plasma (PRP) and injectable platelet-rich fibrin (I-PRF). This study aims to evaluate the efficacy of platelet-rich fibrin (I-PRF) intra-articular injections in managing internal derangements of temporomandibular.
methodsTwenty patients suffering from a unilateral click due to temporomandibular disorders were individually injected with 1 mL of (I-PRF) twice 1 week apart into the superior joint space of the TMJ with the internal disorder. Data were recorded and evaluated by the Helkimo index. This evaluation was conducted three times; 1 week after the first injection, 1 week after the second injection, and 6 months after the first injection.
resultsThe clicking disappeared entirely in 14 out of 20 patients after 1 week of getting the first injection, and in all patients after 1 week of getting the second injection, and returned to two of them after a six-month since the first injection.
conclusionPreliminary results showed the efficacy of the Injectable Platelet-Rich Fibrin (I-PRF) in managing articular clicking in patients with internal disorders of the temporomandibular joint. Injectable Platelet Rich Fibrin has significant clinical efficacy in treating the articular clicking resulting from internal temporomandibular joint disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.