Evidence map›Paper›PMID 35568817›Full record

ArticleBMC cardiovascular disorders2022

Novel biomarkers of inflammation in heart failure with preserved ejection fraction: analysis from a large prospective cohort study.

Nicholas W Carris, Rahul Mhaskar, Emily Coughlin, Easton Bracey, Srinivas M Tipparaju, Ganesh V Halade

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nicholas W CarrisTaneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd MDC 30, Tampa, FL, 33612, USA. carris@usf.edu.ORCID 0000-0001-8904-5034
Rahul MhaskarMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL, 33602, USA.
Emily CoughlinMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL, 33602, USA.
Easton BraceyTaneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd MDC 30, Tampa, FL, 33612, USA.
Srinivas M TipparajuTaneja College of Pharmacy, University of South Florida, 12901 Bruce B. Downs Blvd MDC 30, Tampa, FL, 33612, USA.
Ganesh V HaladeMorsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL, 33602, USA. ghalade@usf.edu.ORCID 0000-0002-5351-9354
University of South Florida · US

Funding

Protecting the Diabetic Skeletal Muscle by Nampt ActivationR01DK119066 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI BROTTO, MARCO, TIPPARAJU, SRINIVAS M. · 2019 to 2023
$2.0M
Resolution of Inflammation in Heart Failure Post-Myocardial InfarctionR01HL132989 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2016 to 2020
$1.8M
Lipoxygenase Signaling in Heart Failure PathologyR01HL144788 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI HALADE, GANESH V · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL132989NHLBI NIH HHS R01 HL144788NIDDK NIH HHS R01 DK119066
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) is a syndrome with a heterogeneous cluster of causes, including non-resolving inflammation, endothelial dysfunction, and multi-organ defects. The present study's objective was to identify novel predictors of HFpEF.

methodsThe study analyzed the Multi-Ethnic Study of Atherosclerosis (MESA) to assess the association of specific markers of inflammation with new onset of HFpEF (interleukin-2 [IL-2], matrix metalloproteinase 3 [MMP3], large low-density lipoprotein cholesterol [LDL-C], and medium high-density lipoprotein cholesterol [HDL-C]). The study included men and women 45 to 84 years of age without cardiovascular disease at baseline. The primary outcome was the multivariate association of the hypothesized markers of inflammation with new-onset of HFpEF versus participants without new-onset heart failure. Participants with missing data were excluded.

resultsThe present analysis included 6814 participants, 53% female, with a mean age of 62 years. Among the entire cohort, HFpEF was diagnosed in 151 (2.2%) participants and heart failure with reduced ejection fraction (HFrEF) was diagnosed in 146 (2.1%) participants. Participants were followed for the outcome of heart failure for a median 13.9 years. Baseline IL-2 was available for 2861 participants. The multivariate analysis included 2792 participants. Of these, 2668 did not develop heart failure, 62 developed HFpEF, 47 developed HFrEF, and 15 developed unclassified heart failure. In the multivariate regression model, IL-2 was associated with new-onset HFpEF (OR, 1.00058; 95% confidence interval, 1.00014 to 1.00102, p = 0.009) but not new-onset HFrEF. In multivariate analysis, MMP3, large LDL-C, and medium HDL-C were not associated with HFpEF or HFrEF.

conclusionThese findings portend IL-2 as an important component of suboptimal inflammation in the pathogenesis of HFpEF.

Indexed as

Heart FailureBiomarkersCholesterol, LDLCohort StudiesFemaleHumansInflammationInterleukin-2MaleMatrix Metalloproteinase 3Middle AgedPrognosisProspective StudiesStroke VolumeBiomarkersCholesterol, LDLInterleukin-2Matrix Metalloproteinase 3Cardiovascular diseaseHeart failureInflammationInterleukin-2

Identifiers

PMID35568817
PMCPMC9107006
OpenAlexW4280537655

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.