Evidence map›Paper›PMID 35568812›Full record

ArticleBMC anesthesiology2022

Outcomes and risk factors for delayed-onset postoperative respiratory failure: a multi-center case-control study by the University of California Critical Care Research Collaborative (UC

Jacqueline C Stocking, Christiana Drake, J Matthew Aldrich, Michael K Ong, Alpesh Amin, Rebecca A Marmor, Laura Godat, Maxime Cannesson, Michael A Gropper, Patrick S Romano and 4 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Jacqueline C StockingDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California Davis, 4150 V Street, Suite 3400, Sacramento, CA, 95817, USA. jcstocking@ucdavis.edu.ORCID 0000-0003-0775-684X
Christiana DrakeDepartment of Statistics, University of California Davis, Davis, CA, USA.
J Matthew AldrichDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.
Michael K OngDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Alpesh AminDepartment of Medicine, University of California Irvine, Irvine, CA, USA.
Rebecca A MarmorDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Laura GodatDepartment of Surgery, University of California San Diego, San Diego, CA, USA.
Maxime CannessonDepartment of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Michael A GropperDepartment of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA.
Patrick S RomanoDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California Davis, 4150 V Street, Suite 3400, Sacramento, CA, 95817, USA.
Christian SandrockDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California Davis, 4150 V Street, Suite 3400, Sacramento, CA, 95817, USA.
Christian BimeCollege of Medicine, University of Arizona Health Sciences, Tucson, AZ, USA.
Ivo AbrahamCenter for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, AZ, USA.
Garth H UtterCenter for Healthcare Policy and Research, University of California Davis, Sacramento, CA, USA.
Center For Policy Research · USUniversity of Arizona · USUniversity of California, Davis · USUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of California, San Francisco · USUniversity of California, Irvine · USUniversity of California System · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
Translational Approaches to Health Disparities in Lung, Sleep, and PandemicsR25HL126140 · NHLBI · UNIVERSITY OF ARIZONA · PI FRANCISCO A MORENO, JANKO Z. NIKOLICH · 2014 to 2026
$4.6M
NCATS NIH HHS UL1 TR000002
6 · The paper itself

Abstract

backgroundFew interventions are known to reduce the incidence of respiratory failure that occurs following elective surgery (postoperative respiratory failure; PRF). We previously reported risk factors associated with PRF that occurs within the first 5 days after elective surgery (early PRF; E-PRF); however, PRF that occurs six or more days after elective surgery (late PRF; L-PRF) likely represents a different entity. We hypothesized that L-PRF would be associated with worse outcomes and different risk factors than E-PRF.

methodsThis was a retrospective matched case-control study of 59,073 consecutive adult patients admitted for elective non-cardiac and non-pulmonary surgical procedures at one of five University of California academic medical centers between October 2012 and September 2015. We identified patients with L-PRF, confirmed by surgeon and intensivist subject matter expert review, and matched them 1:1 to patients who did not develop PRF (No-PRF) based on hospital, age, and surgical procedure. We then analyzed risk factors and outcomes associated with L-PRF compared to E-PRF and No-PRF.

resultsAmong 95 patients with L-PRF, 50.5% were female, 71.6% white, 27.4% Hispanic, and 53.7% Medicare recipients; the median age was 63 years (IQR 56, 70). Compared to 95 matched patients with No-PRF and 319 patients who developed E-PRF, L-PRF was associated with higher morbidity and mortality, longer hospital and intensive care unit length of stay, and increased costs. Compared to No-PRF, factors associated with L-PRF included: preexisiting neurologic disease (OR 4.36, 95% CI 1.81-10.46), anesthesia duration per hour (OR 1.22, 95% CI 1.04-1.44), and maximum intraoperative peak inspiratory pressure per cm H

conclusionsWe identified that pre-existing neurologic disease, longer duration of anesthesia, and greater maximum intraoperative peak inspiratory pressures were associated with respiratory failure that developed six or more days after elective surgery in adult patients (L-PRF). Interventions targeting these factors may be worthy of future evaluation.

Indexed as

Postoperative ComplicationsRespiratory InsufficiencyAdultAgedCase-Control StudiesCritical CareElective Surgical ProceduresFemaleHumansLength of StayMaleMedicareMiddle AgedRetrospective StudiesRisk FactorsUnited StatesElective surgeryMatched case-control study, AHRQ PSI 11PostoperativeRespiratory failureRisk factorsSurgical outcomes

Identifiers

PMID35568812
PMCPMC9107656
OpenAlexW4280488836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.