Evidence map›Paper›PMID 35568803›Full record

ArticleBMC gastroenterology2022

Risk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study.

Ro-Ting Lin, Pei-Lung Chen, Chi-Ying Yang, Chun-Chieh Yeh, Chun-Che Lin, Wen-Hsin Huang, An-Ko Chung, Jaw-Town Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ro-Ting LinDepartment of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, 406040, Taiwan.
Pei-Lung ChenDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, 100226, Taiwan.
Chi-Ying YangDepartment of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, 404332, Taiwan.
Chun-Chieh YehDepartment of Surgery, China Medical University Hospital, Taichung, 404332, Taiwan.
Chun-Che LinDepartment of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, 404332, Taiwan.
Wen-Hsin HuangDepartment of Internal Medicine, Digestive Medicine Center, China Medical University Hospital, Taichung, 404332, Taiwan.
An-Ko ChungGraduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, 100025, Taiwan.
Jaw-Town LinDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, No. 1, Yida Rd., Yanchao Dist., Kaohsiung, 824005, Taiwan. jawtown@gmail.com.

Funding

China Medical University Hospital, Taiwan C1090728010China Medical University Hospital, Taiwan DMR 109-215China Medical University, Taiwan CMU109-S-30Ministry of Science and Technology, Taiwan MOST 109-2327-B-039-001Ministry of Science and Technology, Taiwan MOST 110-2314-B-039-027-MY3Ministry of Science and Technology, Taiwan MOST 110-2314-B-039-058
6 · The paper itself

Abstract

backgroundIncreased pancreatic cancer incidence has been observed among younger than in older adults. This pilot study aimed to determine the feasibility of a large study that would compare the age at diagnosis of pancreatic cancer among patients with different risk factors.

methodsWe compared the age at diagnosis of pancreatic cancer between groups of pancreatic cancer patients exposed and not exposed to the identified risk factors. We estimated the age at which exposure started, average exposure quantity, and total years of exposure and investigated their relationships with age at diagnosis of pancreatic cancer.

resultsSixteen out of 24 (67%) subjects carried known genetic factors and/or had smoking and/or drinking habits; however, an earlier age of pancreatic cancer diagnosis was not observed. Conversely, we found a significant correlation between the age at which alcohol consumption was started and the age at diagnosis of pancreatic cancer (r = 0.8124, P = 0.0043).

conclusionsOur pilot study suggested that a large study following this study design is feasible and that the following should be conducted in a large study: mediation analysis for disease-related factors, advanced genomic analysis for new candidate genes, and the correlation between age of first exposure to risk factors and pancreatic cancer onset.

Indexed as

Pancreatic NeoplasmsAgedAlcohol DrinkingHumansPilot ProjectsRetrospective StudiesRisk FactorsAge at diagnosisAlcohol drinkingGeneticsPancreatic cancerRisk factors

Identifiers

PMID35568803
PMCPMC9107247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.