ArticleThe ISME journal2022
Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats.
Article in The ISME journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Multi-omics time-series analysis in microbiome research: a systematic review.Briefings in bioinformatics · 2025Pooled it
- Metagenomic insights into mangrove lignocellulolytic bacteria and functional analysis of a glucose-tolerant GH 1 β-glucosidase.3 Biotech · 2026Article
- Comparative metagenomic and metatranscriptomic analyses reveal the role of the gayal rumen and hindgut microbiome in high-efficiency lignocellulose degradation.Journal of animal science and biotechnology · 2026Article
- Gut microbiome plasticity explains the altitudinal distribution pattern and adaptability in a small mammal species (Microbiology spectrum · 2026Article
- Characterization of aFrontiers in cellular and infection microbiology · 2026Article
- You are what your fungus eats: diet shapes the microbial garden of a fungus-growing ant.NPJ biofilms and microbiomes · 2025Article
- The Influence of Diet on the Composition and Function of Gut Microbiota in Four Snake Species.Ecology and evolution · 2025Article
- Evolutionary and Ecological Drivers of Gut Microbiota in Wild Rodent Species from the Yucatán Peninsula.Microbial ecology · 2025Article
- Effects of Supplementation with Chlorogenic Acid-Rich Extract fromVeterinary sciences · 2025Article
- Impact of Vitamin B12 Supplementation on Cardiovascular Health in the Silver Star Bamboo Rat, a Species That Feeds Primarily on Bamboo.Animals : an open access journal from MDPI · 2025Article
- Feasibility of Bamboo Sawdust as Sustainable Alternative Substrate forJournal of fungi (Basel, Switzerland) · 2025Article
- The Assembly of Fish Gut Microbiomes Through Habitat Variation Provides Insight Into Redbelly Tilapia Invading a Large Subtropical River.Ecology and evolution · 2025Article
- Dietary preferences affect the gut microbiota of three snake species (Squamata: Colubridae).Frontiers in microbiology · 2025Article
- Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice.International journal of molecular sciences · 2024Article
- Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts.PLoS pathogens · 2024Article
- The Response of the Gut Physiological Function and Microbiome of a Wild Freshwater Fish (International journal of molecular sciences · 2024Article
- Comparative Analysis of Gut Microbiomes in Laboratory Chinchillas, Ferrets, and Marmots: Implications for Pathogen Infection Research.Microorganisms · 2024Article
- Gut microbiota reflect adaptation of cave-dwelling tadpoles to resource scarcity.The ISME journal · 2024Article
- Age-related compositional and functional changes in the adult and breastfed buffalo rumen microbiome.Frontiers in microbiology · 2024Article
- Microbiome Diversity and Cellulose Decomposition Processes by Microorganisms on the Ancient Wooden Seawall of Qiantang River of Hangzhou, China.Microbial ecology · 2023Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
Bamboo rats (Rhizomys pruinosus) are among the few mammals that lives on a bamboo-based diet which is mainly composed of lignocellulose. However, the mechanisms of adaptation of their gut microbiome and metabolic systems in the degradation of lignocellulose are largely unknown. Here, we conducted a multi-omics analysis on bamboo rats to investigate the interaction between their gut microbiomes and metabolic systems in the pre- and post-weaning periods, and observed significant relationships between dietary types, gut microbiome, serum metabolome and host gene expression. For comparison, published gut microbial data from the famous bamboo-eating giant panda (Ailuropoda melanoleuca) were also used for analysis. We found that the adaptation of the gut microbiome of the bamboo rat to a lignocellulose diet is related to a member switch in the order Bacteroidales from family Bacteroidaceae to family Muribaculaceae, while for the famous bamboo-eating giant panda, several aerobes and facultative anaerobes increase after weaning. The conversion of bacteria with an increased relative abundance in bamboo rats after weaning enriched diverse carbohydrate-active enzymes (CAZymes) associated with lignocellulose degradation and functionally enhanced the biosynthesis of amino acids and B vitamins. Meanwhile, the circulating concentration of short-chain fatty acids (SCFAs) derived metabolites and the metabolic capacity of linoleic acid in the host were significantly elevated. Our findings suggest that fatty acid metabolism, including linoleic acid and SCFAs, are the main energy sources for bamboo rats in response to the low-nutrient bamboo diet.
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