Evidence map›Paper›PMID 35568756›Full record

ArticleBone marrow transplantation2022

Comparison of fludarabine-melphalan and fludarabine-treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation-a registry study on behalf of the EBMT Acute Leukemia Working Party.

Jesus Duque-Afonso, Jürgen Finke, Myriam Labopin, Charles Craddock, Rachel Protheroe, Panagiotis Kottaridis, Eleni Tholouli, Jenny L Byrne, Kim Orchard, Urpu Salmenniemi and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Bone marrow transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 19 institutions in 6 countries.

Jesus Duque-AfonsoDepartment of Hematology/Oncology, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany. jesus.duque.afonso@uniklinik-freiburg.de.ORCID 0000-0002-8287-5673
Jürgen FinkeDepartment of Hematology/Oncology, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany.
Myriam LabopinEBMT Paris Study Office, Hopital Saint Antoine, Paris, France.ORCID 0000-0003-4514-4748
Charles CraddockBirmingham Centre for Cellular Therapy and Transplantation, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK.ORCID 0000-0001-5041-6678
Rachel ProtheroeUniversity Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
Panagiotis KottaridisDepartment of Haematology, University College London Hospital, London, UK.
Eleni TholouliClinica Haematology Department, Manchester Royal Infirmary, Manchester, UK.
Jenny L ByrneNottingham University, Hucknall Road, Nottingham, UK.
Kim OrchardWessex Blood and Marrow Transplant and Cellular Therapy Program, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Urpu SalmenniemiStem Cell Transplantation Unit, HUCH Comprehensive Cancer Center, Helsinki, Finland.
Inken HilgendorfUniversitaetsklinikum Jena, Klinik für Innere Medizin II, (Abt. Hämatologie und Onkologie), Am Klinikum 1, Jena, Germany.ORCID 0000-0003-2038-9730
Hannah HunterUniversity Hospitals Plymouth NHS Trust, Derriford Hospital, Plymouth, UK.
Emma NicholsonDepartment of Haematology, Royal Marsden Hospital, London, UK.
Adrian BloorThe Christie NHS Foundation Trust, Stem Cell Transplantation Unit, University of Manchester, Manchester, UK.ORCID 0000-0003-4550-220X
John A SnowdenSheffield Teaching Hospitals NHS Trust, Royal Hallamshire Hospital, Sheffield, UK.ORCID 0000-0001-6819-3476
Mareike VerbeekKlinikum Rechts der Isar, III Med Klinik der TU, Munich, Germany.
Andrew ClarkBone Marrow Transplant Unit, Beatson, West of Scotland Cancer Centre, Gartnaval General Hospital, Glasgow, UK.
Bipin N SavaniDivision of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Alexandros SpyridonidisUniversity Hospital of Patras, Patras, Greece.ORCID 0000-0003-3097-2532
Arnon NaglerHematology Division, Chaim Sheba Medical Center, Tel Hashomer, Israel.ORCID 0000-0002-0763-1265
Mohamad MohtySorbonne University, Saint-Antoine Hospital, AP-HP, INSERM UMRs 938, Paris, France. mohamad.mohty@inserm.fr.ORCID 0000-0002-7264-808X
University of Freiburg · DEBeatson West of Scotland Cancer Centre · GBDerriford Hospital · GBGeneral University Hospital of Patras · GRInserm · FRKlinikum Magdeburg · DEManchester Royal Infirmary · GBQueen Elizabeth Hospital Birmingham · GBRoyal Hallamshire Hospital · GBRoyal Marsden Hospital · GBSheba Medical Center · ILSorbonne Université · FRTUM Klinikum · DEUniversity College Hospital · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Manchester · GBUniversity of Nottingham · GBVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years considerable variations in conditioning protocols for allogeneic hematopoietic cell transplantation (allo-HCT) protocols have been introduced for higher efficacy, lower toxicity, and better outcomes. To overcome the limitations of the classical definition of reduced intensity and myeloablative conditioning, a transplantation conditioning intensity (TCI) score had been developed. In this study, we compared outcome after two frequently used single alkylator-based conditioning protocols from the intermediate TCI score category, fludarabine/melphalan 140 mg/m

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteAcute DiseaseAdultBone Marrow TransplantationBusulfanHumansMelphalanMiddle AgedRegistriesRetrospective StudiesTransplantation ConditioningVidarabineBusulfanfludarabineMelphalantreosulfanVidarabine

Identifiers

PMID35568756
PMCPMC9352579
OpenAlexW4280498231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.