ArticleJournal of human hypertension2023
Individuals with hypertension have lower plasma volume regardless of weight status.
Article in Journal of human hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mineralocorticoid Receptor Blockade Mitigates Loop Diuretic-Exacerbated Plasma Volume Contraction and Target-Organ Fibrosis in Angiotensin II-Induced Hypertension.International journal of molecular sciences · 2026Article
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Authors and funding
3 authors.
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Abstract
Increased plasma volume is often reported as a cause or symptom of hypertension in individuals with obesity. However, these individuals are often compared to normal weight normotensive individuals. Since higher plasma volumes have been reported in larger individuals, it is possible that plasma volume is actually lower in obese hypertensive individuals compared to normotensive obese individuals. This may be important for better understanding the clinical manifestation of hypertension between weight categories. National Health and Nutritional Examination Survey (cycles 1999-2018) data were used to examine the relationship between plasma (derived from the Straus formula), blood pressure (measured with an automated device) and body mass index. We observed an inverse relationship between estimated plasma volume and systolic (B = -1.68 (95% CI: -2.06, -1.30) mmHg), p < 0.0001), diastolic (B = -3.35 (95% CI: -3.61, -3.08) mmHg) p < 0.0001), and mean arterial pressure (B = -2.79 (95% CI: -3.05, -2.53) mmHg) p < 0.0001). The relationship between estimated plasma volume and diastolic blood pressure (interaction term: B = -0.069 (-0.10, -0.03), p < 0.0001) did depend on BMI. The "normal weight" group had the lowest slope and this slope was significantly different from the "obese" (B = -1.47 (95% CI: -1.88, -1.07)) and "overweight" (B = -1.11 (-1.55, -0.67)) groups. Plasma volume is lower in hypertensive individuals regardless of weight status, but this relationship is more pronounced among obese individuals.
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