ArticleLife science alliance2022
Open access · goldAbstract read
In one paragraph
Article in Life science alliance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026Review
- Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration inInternational journal of molecular sciences · 2026Article
- Genetic Basis of Motor Neuron Diseases: Insights, Clinical Management, and Future Directions.International journal of molecular sciences · 2025Review
- RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.Life science alliance · 2025Article
- Modeling ALS with Patient-Derived iPSCs: Recent Advances and Future Potentials.Brain sciences · 2025Review
- ALS' Perfect Storm:Cells · 2024Review
- Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity.Acta neuropathologica communications · 2023Article
- Article
- Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.Cells · 2023Review
- Why should we care about astrocytes in a motor neuron disease?Frontiers in molecular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 2 institutions in 2 countries.
Paolo M MarchiSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8893-3790
Lara MarroneSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0001-8365-8411
Laurent BrasseurThe French Alternative Energies and Atomic Energy Commission (CEA), Institut François Jacob (MIRcen) and The French National Centre for Scientific Research (CNRS), Laboratory of Neurodegenerative Diseases (UMR9199), Fontenay-aux-Roses, France.
Audrey CoensThe French Alternative Energies and Atomic Energy Commission (CEA), Institut François Jacob (MIRcen) and The French National Centre for Scientific Research (CNRS), Laboratory of Neurodegenerative Diseases (UMR9199), Fontenay-aux-Roses, France.
Christopher P WebsterSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0003-4197-2036
Luc BoussetThe French Alternative Energies and Atomic Energy Commission (CEA), Institut François Jacob (MIRcen) and The French National Centre for Scientific Research (CNRS), Laboratory of Neurodegenerative Diseases (UMR9199), Fontenay-aux-Roses, France.
Marco DestroSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Emma F SmithSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Christa G WaltherThe Wolfson Light Microscopy Facility, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8962-3102
Victor AlfredSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0002-5083-8798
Raffaele MarroccellaSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Emily J GravesSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Darren RobinsonThe Wolfson Light Microscopy Facility, University of Sheffield, Sheffield, UK.ORCID 0000-0002-7170-2486
Allan C ShawSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0002-7321-7994
Lai Mei WanSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Andrew J GriersonSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Stephen J EbbensDepartment of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK.ORCID 0000-0002-4727-4426
Kurt J De VosSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.
Guillaume M HautbergueSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0002-1621-261X
Laura FerraiuoloSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0001-9118-5714
Ronald MelkiThe French Alternative Energies and Atomic Energy Commission (CEA), Institut François Jacob (MIRcen) and The French National Centre for Scientific Research (CNRS), Laboratory of Neurodegenerative Diseases (UMR9199), Fontenay-aux-Roses, France ronald.melki@cnrs.fr m.azzouz@sheffield.ac.uk.ORCID 0000-0003-0000-7096
Mimoun AzzouzSheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, Sheffield, UK ronald.melki@cnrs.fr m.azzouz@sheffield.ac.uk.ORCID 0000-0001-6564-5967
University of Sheffield · GBCentre National de la Recherche Scientifique · FR
Funding
Biotechnology and Biological Sciences Research Council BB/S005277/1European Research Council 294745Medical Research Council 129016Medical Research Council 1812144Medical Research Council MR/K015753/1Medical Research Council MR/M013251/1Medical Research Council MR/R024162/1Medical Research Council MR/S025979/1Medical Research Council MR/V000470/1Medical Research Council MR/W00416X/1Motor Neurone Disease Association DEVOS/APR18/862-791Motor Neurone Disease Association DEVOS/OCT13/870-792
Abstract
Dipeptide repeat (DPR) proteins are aggregation-prone polypeptides encoded by the pathogenic GGGGCC repeat expansion in the
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaDipeptidesHumansMotor NeuronsC9orf72 ProteinC9orf72 protein, humanDipeptides
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.