ArticleCell2022
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling.
Open access · hybridAbstract read
In one paragraph
Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Multifunctional antibody responses from a primateScience translational medicine · 2026Article
- Tumor-infiltrating B cells evolve towards interferon-rich trajectories aligned with immunotherapy in melanoma.Journal of experimental & clinical cancer research : CR · 2026Article
- LISS enables immune evasion of colorectal cancers irrespective of MSI status.Signal transduction and targeted therapy · 2026Article
- Gingipain proteases from the bacteriumProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Helicobacter pylori-induced PPFIA4 orchestrates immune network-promoting gastritis and gastric bacterial colonization.The Journal of clinical investigation · 2026Article
- Article
- Danhong Injection targets CaMKII through Dihydrotanshinone I to alleviate cardiomyocyte death and inflammation in viral myocarditis.Science China. Life sciences · 2026Article
- A bacterial YopJ-family acetyltransferase suppresses host immune response by Nε-acetylation of JAK1.Nature communications · 2026Article
- Shigella flexneri evades septin-mediated cell-autonomous immunity via protein ADP-riboxanation.Nature communications · 2026Article
- Structure and mechanism of an actin-dependent bacterial phosphoryl AMPylase.Nature chemical biology · 2026Article
- Astrocyte-derived HMGB1 compromises the integrity of the blood-brain barrier through the CaM/CaMKII/AQP4 pathway and the protective function of trifluoperazine.Frontiers in immunology · 2026Article
- Intestinal LGR4 Signalling Alters Bacterial translocation, Intrahepatic Microbiota composition, and Type 1 Interferon Expression in Murine Liver Fibrosis.Inflammation · 2025Article
- Protective and pathogenic antibody responses from a primate Shigella outbreak inform vaccine design.bioRxiv : the preprint server for biology · 2025Article
- Differential targeting of human pyroptotic Caspase-5 and Caspase-4 bybioRxiv : the preprint server for biology · 2025Article
- TheeLife · 2025Article
- Shigella type-III secretion system effectors counteract the induction of host inflammation and cell death.The EMBO journal · 2025Article
- Post-translational weapons of microbial warfare: how bacterial effectors hijack host cell death and xenophagy.Cell communication and signaling : CCS · 2025Review
- Interferons in health and disease.Cell · 2025Review
- Multifunctional piezoelectric hydrogels under ultrasound stimulation boost chondrogenesis by recruiting autologous stem cells and activating the CaBioactive materials · 2025Article
- ThebioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Commented on by
Authors and funding
24 authors at 6 institutions in 3 countries.
Noémie AlphonseDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK; Immunoregulation Laboratory, Francis Crick Institute, London, UK.
Joseph J WanfordDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Andrew A VoakDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Jack GayDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Shayla VenkhayaDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Owen BurroughsDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Sanjana MathewDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Truelian LeeCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Sasha L EvansRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Weiting ZhaoDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Kyle FrowdeDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Abrar AlrehailiDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Ruth E DickensonDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Mads MunkDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
Svetlana PaninaDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
Ishraque F MahmoodDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.
Miriam LlorianBioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
Megan L StaniferDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA.
Steeve BoulantDepartment of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA.
Martin W BerchtoldDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
Julien R C BergeronRandall Centre for Cell and Molecular Biophysics, King's College London, London, UK.
Andreas WackImmunoregulation Laboratory, Francis Crick Institute, London, UK.
Cammie F LesserCenter for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Charlotte OdendallDepartment of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK. Electronic address: charlotte.odendall@kcl.ac.uk.
King's College London · GBUniversity of Copenhagen · DKThe Francis Crick Institute · GBUniversity of Florida · USBroad Institute · USMassachusetts General Hospital · US
Funding
Modeling mechanisms of Shigella pathogenesis in yeastR01AI064285 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LESSER, CAMMIE · 2006 to 2017
$4.0MBiotechnology and Biological Sciences Research Council BB/R009759/2Cancer Research UKMedical Research Council MR/N013700/1NIAID NIH HHS R01 AI064285Wellcome Trust 206200/Z/17/ZWellcome Trust FC001206
Abstract
Interferons (IFNs) induce an antimicrobial state, protecting tissues from infection. Many viruses inhibit IFN signaling, but whether bacterial pathogens evade IFN responses remains unclear. Here, we demonstrate that the Shigella OspC family of type-III-secreted effectors blocks IFN signaling independently of its cell death inhibitory activity. Rather, IFN inhibition was mediated by the binding of OspC1 and OspC3 to the Ca
Indexed as
InterferonsVirulence FactorsAnimalsAntiviral AgentsCalcium SignalingEpithelial CellsMiceAntiviral AgentsInterferonsVirulence FactorsCa(2+)calciumcalmodulinCaMKIIhost-pathogen interactionsinterferonsISGJAK/STATOspC1OspC3ShigellaT3SS
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.