ArticleAdvances in experimental medicine and biology2022
Development of αβ T Cells with Innate Functions.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Although we mostly think of αβ T cells as components of the adaptive immune system, a number of them differentiate into alternative lineages. These lineages express TCRs with limited diversity, and functionally bridge the gap between innate and adaptive immunity. They tend to be tissue resident, and mount potent cytokine responses very rapidly after activation, and their development and functional maturation are strongly influenced by the microbiome. Here, we compare the development pathways and interactions with the microbiome of natural killer T (NKT) cells and mucosal-associated invariant T (MAIT cells), the two best studied "innate-like" αβ T cell populations.
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