ArticleEuropean journal of nuclear medicine and molecular imaging2022
Development and validation of a radiomic model for the diagnosis of dopaminergic denervation on [18F]FDOPA PET/CT.
Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 13 citations in OpenAlex.
- Combined with multimodal medical imaging and artificial intelligence for early diagnosis of Parkinson's disease.Frontiers in neurology · 2025Article
- Radiomics incorporating deep features for predicting Parkinson's disease inEJNMMI physics · 2024Article
- Towards an Automated Approach to the Semi-Quantification of [Journal of clinical medicine · 2023Article
- Relevance ofEJNMMI research · 2023Article
- Radiomics insight into the neurodegenerative "Frontiers in nuclear medicine · 2023Review
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6 authors at 4 institutions in 1 country.
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Abstract
purposeFDOPA PET shows good performance for the diagnosis of striatal dopaminergic denervation, making it a valuable tool for the differential diagnosis of Parkinsonism. Textural features are image biomarkers that could potentially improve the early diagnosis and monitoring of neurodegenerative parkinsonian syndromes. We explored the performances of textural features for binary classification of FDOPA scans.
methodsWe used two FDOPA PET datasets: 443 scans for feature selection, and 100 scans from a different PET/CT system for model testing. Scans were labelled according to expert interpretation (dopaminergic denervation versus no dopaminergic denervation). We built LASSO logistic regression models using 43 biomarkers including 32 textural features. Clinical data were also collected using a shortened UPDRS scale.
resultsThe model built from the clinical data alone had a mean area under the receiver operating characteristics (AUROC) of 63.91. Conventional imaging features reached a maximum score of 93.47 but the addition of textural features significantly improved the AUROC to 95.73 (p < 0.001), and 96.10 (p < 0.001) when limiting the model to the top three features: GLCM_Correlation, Skewness and Compacity. Testing the model on the external dataset yielded an AUROC of 96.00, with 95% sensitivity and 97% specificity. GLCM_Correlation was one of the most independent features on correlation analysis, and systematically had the heaviest weight in the classification model.
conclusionA simple model with three radiomic features can identify pathologic FDOPA PET scans with excellent sensitivity and specificity. Textural features show promise for the diagnosis of parkinsonian syndromes.
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