Evidence map›Paper›PMID 35567266›Full record

ReviewPlants (Basel, Switzerland)2022

Phytochemicals and Nano-Phytopharmaceuticals Use in Skin, Urogenital and Locomotor Disorders: Are We There?

Mogana Rajagopal, Alok K Paul, Ming-Tatt Lee, Anabelle Rose Joykin, Choo-Shiuan Por, Tooba Mahboob, Cristina C Salibay, Mario S Torres, Maria Melanie M Guiang, Mohammed Rahmatullah and 6 more

Abstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mogana RajagopalFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-5664-9293
Alok K PaulSchool of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, Australia.
Ming-Tatt LeeFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.ORCID 0000-0003-3957-2439
Anabelle Rose JoykinFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.
Choo-Shiuan PorFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia.
Tooba MahboobSchool of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat 80160, Thailand.
Cristina C SalibayBiologica Sciences Department, College of Science and Computer Studies, De La Salle University, Dasmarinas 4114, Philippines.
Mario S TorresBiologica Sciences Department, College of Science and Computer Studies, De La Salle University, Dasmarinas 4114, Philippines.
Maria Melanie M GuiangDepartment of Biology, College of Arts and Sciences, Central Mindanao University, Bukidnon 8710, Philippines.
Mohammed RahmatullahDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.ORCID 0000-0002-0216-7977
Rownak JahanDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
Khoshnur JannatDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Lalmatia, Dhaka 1207, Bangladesh.
Polrat WilairatanaDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.ORCID 0000-0002-2730-7788
Maria de Lourdes PereiraCICECO-Aveiro Institute of Materials, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.ORCID 0000-0001-6703-7869
Chooi Ling LimDivision of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur 57000, Malaysia.
Veeranoot NissapatornSchool of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat 80160, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and the improvements of nanoparticles has been of keen interest in multiple industries, including pharmaceutics, diagnostics, electronics, communications, and cosmetics. In herbal medicines, these nanoparticles have several attractive properties that have brought them to the forefront in searching for novel drug delivery systems by enhancing efficacy, bioavailability, and target specificity. The current review investigated various therapeutic applications of different nano-phytopharmaceuticals in locomotor, dermal, reproductive, and urinary tract disorders to enhance bioavailability and efficacy of phytochemicals and herbal extracts in preclinical and in vitro studies. There is a lack of clinical and extensive preclinical studies. The research in this field is expanding but strong evidence on the efficacy of these nano-phytopharmaceuticals for human use is still limited. The long-term efficacy and safety of nano-phytopharmaceuticals must be ensured with priority before these materials emerge as common human therapeutics. Overall, this review provides up-to-date information on related contemporary research on nano-phytopharmaceuticals and nano-extracts in the fields of dermatological, urogenital, and locomotor disorders.

Indexed as

dermal disorderlocomotor disordernanomaterialsphytopharmaceuticalsurogenital disorder

Identifiers

PMID35567266
PMCPMC9099949

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.