ArticlePlants (Basel, Switzerland)2022
Chemical Composition, Enantiomeric Distribution and Anticholinesterase and Antioxidant Activity of the Essential Oil of
Article in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Plant Essential Oil with Biological Activity (II).Plants (Basel, Switzerland) · 2023Article
- Study of Essential Oil Isolated from Achiote (Antibiotics (Basel, Switzerland) · 2023Article
- Study of the Chemical Composition and Biological Activity of the Essential Oil from Congona (Plants (Basel, Switzerland) · 2023Article
- Chemical Composition, Enantiomeric Distribution and Biological Activity of Essential Oil fromMolecules (Basel, Switzerland) · 2023Article
- Chemical Evaluation, Phytotoxic Potential, and In Silico Study of Essential Oils from Leaves ofMolecules (Basel, Switzerland) · 2023Article
- Chemical Profiling of Hedyosmum cumbalense and Hedyosmum spectabile (Chloranthaceae) Essential Oils, and Their Antimicrobial, Antioxidant, and Anticholinesterase PropertiesPlants (Basel, Switzerland) · 2022Article
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Abstract
The aim of this study was to extract and identify the chemical compounds of Diplosthephium juniperinum essential oil (EO) from Ecuador and to assess its anticholinesterase and antioxidant properties. The EO chemical composition was determined by GC−MS. A total of 74 constituents of EO were identified, representing 97.27% in DB-5ms and 96.06% in HP-INNOWax of the total EO. The major constituents (>4.50%) identified were: α-pinene (21.52, 22.04%), geranyl acetate (10.54, 7.78%), silphiper-fol-5-ene (8.67, 7.38%), α-copaene (8.26, 8.18%), 7-epi-silphiperfol-5-ene (4.93, 5.95%), and germacrene D (4.91, 6.00%). Enantioselective analysis of the volatile fraction of D. juniperinum showed: (+)-α-pinene as a pure enantiomer and 5 pairs of enantiomeric compounds. Among them, (−)-β-Pinene and (−)-Germacrene D presented a high enantiomeric excess of 93.23 and 84.62%, respectively, while (−)-α-Thujene, (−)-Sabinene and (S)-4-Terpineol with a lower enantiomeric excess of 56.34, 47.84 and 43.11%, respectively. A moderate inhibitory effect was observed for Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) enzymes with IC50 values of 67.20 ± 7.10 and 89.00 ± 9.90 µg/mL, respectively. A lower antioxidant potential was observed for the EO measured through DPPH and ABTS radical scavenging assays with SC50 values of 127.03 and >1000 µg/mL, respectively. To the best of our knowledge, this is the first report of the chemical composition, enantiomeric distribution and, anticholinesterase and antioxidant potential of the EO of D. juniperinum. As future perspective, further in-vivo studies could be conducted to confirm the anticholinesterase potential of the EO.
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