Evidence map›Paper›PMID 35566958›Full record

ReviewPolymers2022

Monomer Release from Dental Resins: The Current Status on Study Setup, Detection and Quantification for In Vitro Testing.

Tristan Hampe, Andreas Wiessner, Holm Frauendorf, Mohammad Alhussein, Petr Karlovsky, Ralf Bürgers, Sebastian Krohn

Open access · goldAbstract readReview
In one paragraph

Review in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Assessment of Monomer Release From Resin Composites Following the Use of Various Modeling Liquids.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
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  16. Scots Pine Bark Extracts as Co-Hardeners of Epoxy Resins.Molecules (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tristan HampeDepartment of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany.ORCID 0000-0003-4569-3085
Andreas WiessnerDepartment of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Holm FrauendorfInstitute for Organic and Biomolecular Chemistry, University of Göttingen, 37077 Göttingen, Germany.
Mohammad AlhusseinMolecular Phytopathology and Mycotoxin Research, University of Göttingen, 37077 Göttingen, Germany.
Petr KarlovskyMolecular Phytopathology and Mycotoxin Research, University of Göttingen, 37077 Göttingen, Germany.ORCID 0000-0002-6532-5856
Ralf BürgersDepartment of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Sebastian KrohnDepartment of Prosthodontics, University Medical Center Göttingen, 37075 Göttingen, Germany.
Universitätsmedizin Göttingen · DEUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improvements in mechanical properties and a shift of focus towards esthetic dentistry led to the application of dental resins in various areas of dentistry. However, dental resins are not inert in the oral environment and may release monomers and other substances such as Bisphenol-A (BPA) due to incomplete polymerization and intraoral degradation. Current research shows that various monomers present cytotoxic, genotoxic, proinflammatory, and even mutagenic effects. Of these eluting substances, the elution of BPA in the oral environment is of particular interest due to its role as an endocrine disruptor. For this reason, the release of residual monomers and especially BPA from dental resins has been a cause for public concern. The assessment of patient exposure and potential health risks of dental monomers require a reliable experimental and analytical setup. However, the heterogeneous study design applied in current research hinders biocompatibility testing by impeding comparative analysis of different studies and transfer to the clinical situation. Therefore, this review aims to provide information on each step of a robust experimental and analytical in vitro setup that allows the collection of clinically relevant data and future meta-analytical evaluations.

Indexed as

biocompatibilitybisphenol Aelutionleachingmaterials testingmonomerresin based dental materials

Identifiers

PMID35566958
PMCPMC9100225
OpenAlexW4224981124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.