ArticlePolymers2022
Development of Carboxymethyl Chitosan Nanoparticles Prepared by Ultrasound-Assisted Technique for a Clindamycin HCl Carrier.
Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Decoction-derived bioactive nanoparticles of Lycopodium japonicum Thunb. attenuate knee osteoarthritis by regulating MAPK/ERK signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Antimicrobial potential of different bee product-loaded carboxymethyl chitosan nanoparticles against multidrug-resistant clinical pathogens: a comparative in vitro study.BMC biotechnology · 2026Article
- Augmenting the antimicrobial activity of clindamycin hydrochloride-loaded acrylate polymer/zinc oxide nanocomposites against pathogenic microbes.RSC advances · 2026Article
- Ionizing Radiation Crosslinked Chitosan-Based Hydrogels for Environmental Remediation.Gels (Basel, Switzerland) · 2025Review
- Biodegradable sustained-release microneedle patch loaded with clindamycin hydrochloride: a breakthrough in acne management.Frontiers in pharmacology · 2025Article
- Smart Ultrasound-responsive Polymers for Drug Delivery: An Overview on Advanced Stimuli-sensitive Materials and Techniques.Current drug delivery · 2025Review
- Advances in polymeric nano-delivery systems targeting hair follicles for the treatment of acne.Drug delivery · 2024Review
- Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels.Molecules (Basel, Switzerland) · 2024Review
- Alginate and Chitosan-Based Delivery Systems for Improving the Bioavailability and Therapeutic Efficacy of Curcumin.Pharmaceutics · 2024Review
- The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles.Nanotechnology, science and applications · 2024Review
- Carboxymethyl Chitosan Hydrogels for Effective Wound Healing-An Animal Study.Journal of functional biomaterials · 2023Article
- Carboxymethyl Chitosan Microgels for Sustained Delivery of Vancomycin and Long-Lasting Antibacterial Effects.Gels (Basel, Switzerland) · 2023Article
- A Review on Antibacterial Biomaterials in Biomedical Applications: From Materials Perspective to Bioinks Design.Polymers · 2022Review
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Authors and funding
7 authors.
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Abstract
Polymeric nanoparticles are one method to modify the drug release of small hydrophilic molecules. In this study, clindamycin HCl was used as a model drug loaded in carboxymethyl chitosan nanoparticles cross-linked with Ca2+ ions (CMCS-Ca2+). The ultrasonication with experimental design was used to produce CMCS-Ca2+ nanoparticles loading clindamycin HCl. The model showed that the size of nanoparticles decreased when amplitude and time increased. The nanoparticle size of 318.40 ± 7.56 nm, decreased significantly from 543.63 ± 55.07 nm (p < 0.05), was obtained from 75% of amplitude and 180 s of time, which was one of the optimal conditions. The clindamycin loading content in this condition was 34.68 ± 2.54%. The drug content in nanoparticles showed an inverse relationship with the size of the nanoparticles. The sodium carboxymethylcellulose film loading clindamycin HCl nanoparticles exhibited extended release with 69.88 ± 2.03% drug release at 60 min and a gradual increase to 94.99 ± 4.70% at 24 h, and demonstrated good antibacterial activity against S. aureus and C. acne with 40.72 ± 1.23 and 48.70 ± 1.99 mm of the zone of inhibition at 24 h, respectively. Thus, CMCS-Ca2+ nanoparticles produced by the ultrasound-assisted technique could be a potential delivery system to modify the drug release of small hydrophilic antibiotics.
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