Evidence map›Paper›PMID 35566789›Full record

ArticleJournal of clinical medicine2022

Marginal versus Standard Donors in Heart Transplantation: Proper Selection Means Heart Transplant Benefit.

Olimpia Bifulco, Tomaso Bottio, Raphael Caraffa, Massimiliano Carrozzini, Alvise Guariento, Jonida Bejko, Marny Fedrigo, Chiara Castellani, Giuseppe Toscano, Giulia Lorenzoni and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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  6. Clinical case reports · 2026
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  14. Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) Support in New Era of Heart Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Olimpia BifulcoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
Tomaso BottioDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0001-7299-2983
Raphael CaraffaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0001-9651-3473
Massimiliano CarrozziniCardiothoracovascular Department, Niguarda Hospital, 20162 Milan, Italy.ORCID 0000-0001-5506-0201
Alvise GuarientoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
Jonida BejkoVascular Unit, Portogruaro Hospital, 30026 Portogruaro, Italy.
Marny FedrigoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
Chiara CastellaniDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0002-0275-4864
Giuseppe ToscanoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
Giulia LorenzoniDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0003-1771-4686
Vincenzo TarziaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.
Dario GregoriDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0001-7906-0580
Massimo CardilloItalian National Transplant Centre, National Institute of Health, 00162 Rome, Italy.
Francesca PuotiItalian National Transplant Centre, National Institute of Health, 00162 Rome, Italy.
Giuseppe FeltrinRegional Transplant Centre, 35128 Padua, Italy.
Annalisa AngeliniDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0002-3578-4488
Gino GerosaDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.ORCID 0000-0002-6261-699X
University of Padua · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, we assessed the mid-term outcomes of patients who received a heart donation from a marginal donor (MD), and compared them with those who received an organ from a standard donor (SD).

methodsAll patients who underwent HTx between January 2012 and December 2020 were enrolled at a single institution. The primary endpoints were early and long-term survival of MD recipients. Risk factors for primary graft failure (PGF) and mortality in MD recipients were also analyzed. The secondary endpoint was the comparison of survival of MD versus SD recipients.

resultsIn total, 238 patients underwent HTx, 64 (26.9%) of whom received an organ from an MD. Hospital mortality in the MD recipient cohort was 23%, with an estimated 1 and 5-year survival of 70% (59.2-82.7) and 68.1% (57.1-81), respectively. A multivariate analysis in MD recipients showed that decreased renal function and increased inotropic support of recipients were associated with higher mortality (

conclusionsSelected MDs are a valuable resource for expanding the cardiac donor pool, showing promising results. The use of MDs after prolonged ischemic times, increased inotropic support of the MD or the recipient and decreased renal function are associated with worse outcomes.

Indexed as

heart marginal donorsin-hospital mortalitymid-term survivalstandard donors and marginal donors’ comparison

Identifiers

PMID35566789
PMCPMC9105473
OpenAlexW4229455874

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.