ArticleJournal of clinical medicine2022
The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Pharmacological treatment of schizophrenia: Japanese Expert Consensus 2025.Schizophrenia (Heidelberg, Germany) · 2026Article
- A symptom network approach to schizophrenia in the CATIE study: processing speed as the central cognitive impairment.BJPsych open · 2026Article
- Article
- Interrelationships among oxidative stress, niacin response, cognition, and symptoms in chronic schizophrenia: a case-control study.BMC psychiatry · 2025Observational
- A dimensional approach to psychosis: identifying cognition, depression, and thought disorder factors in a clinical sample.Schizophrenia (Heidelberg, Germany) · 2025Article
- Interrater reliability of the modified Tinkertoy test: A validation study in schizophrenia and control groups.PCN reports : psychiatry and clinical neurosciences · 2025Article
- A potential mechanism for tau protein modulating in schizophrenia with transcranial direct current stimulation intervention: A randomized controlled trial.BioImpacts : BI · 2025Article
- Cognitive impairment across the schizophrenia spectrum: a comparative neuropsychological study.Frontiers in psychiatry · 2025Article
- The Ethiopian Cognitive Assessment battery in Schizophrenia (ECAS): a validation study.Schizophrenia (Heidelberg, Germany) · 2024Article
- Article
- Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia via anti-inflammatory effect: a randomized clinical trial.Chinese medicine · 2023Article
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Authors and funding
14 authors.
Funding
Abstract
Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients.
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