ReviewJournal of clinical medicine2022
Chronic Pain in Musculoskeletal Diseases: Do You Know Your Enemy?
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06460168 (Comparative Effects of Mulligan and Maitland Techniques on Pain, Range of Motion and Functional Disability in Post Prp Knee Osteoarthritis), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effects of Mulligan and Maitland Techniques on Pain, Range of Motion and Functional Disability in Post Prp Knee Osteoarthritis
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Comparison of the effectiveness of high-intensity laser therapy versus low-level laser therapy in musculoskeletal disorders: a systematic review and network meta-analysis.Lasers in medical science · 2026Pooled it
- Efficacy of different intensities of percutaneous electrolysis for musculoskeletal pain: A systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Calcitonin Gene-Related Peptide (CGRP) in Bone Repair and Musculoskeletal Pain: A Scoping Review of Skeletal Regeneration, Joint and Tendon Involvement, and CGRP-Targeted Therapies.Calcified tissue international · 2026Article
- Proximal Hamstring-Related Sciatic Nerve Entrapment Presenting as Recurrent Hamstring Strain in a Professional Footballer: A Case Report.Journal of orthopaedic case reports · 2026Article
- Neuropathic pain and sarcopenia based on skeletal muscle mass assessment following lumbar spinal stenosis surgery: a prospective observational study in Japan.Asian spine journal · 2026Article
- Analysis of serum biomarkers associated with pain in Spanish greyhounds undergoing ovariohysterectomy.The Veterinary record · 2026Article
- Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.Nature communications · 2026Article
- Harpagophytum procumbens in musculoskeletal disorders: current evidence and comparison with NSAIDs.Frontiers in pharmacology · 2026Review
- Multidimensional burden of low back pain: A prospective cross sectional study of patient-reported outcomes and sociodemographic factors at a tertiary neurosurgical center.Brain & spine · 2026Article
- The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.The Journal of the Canadian Chiropractic Association · 2025Article
- Obstacles and facilitators of return to work among people with persistent pain who receive benefit payments: an in-depth interview study.BMC public health · 2025Article
- Prevalence and Risk Factors of Musculoskeletal Pain Among Kuwaiti Pilgrims During Hajj 2024.International journal of environmental research and public health · 2025Article
- Cervical Spine Range of Motion Reliability with Two Methods and Associations with Demographics, Forward Head Posture, and Respiratory Mechanics in Patients with Non-Specific Chronic Neck Pain.Journal of functional morphology and kinesiology · 2025Article
- Evaluating the Real-World Use of Topical Diclofenac Sodium Gel 1% Using US Longitudinal Electronic Health Records Database: A study supporting OTC switch.Pain and therapy · 2025Article
- The Intersection of Sarcopenia and Musculoskeletal Pain: Addressing Interconnected Challenges in Aging Care.International journal of environmental research and public health · 2025Review
- How can Blood Flow Restriction Exercise be Utilised for the Management of Persistent Pain Following Complex Injuries in Military Personnel? A Narrative Review.Sports medicine - open · 2025Review
- An Analysis of Factors Associated with Chronic Musculoskeletal Pain, Pain Management Preferences, Coping Strategies, and Health-Related Quality of Life Among Older People: A Cross-Cultural Study.Journal of pain research · 2025Article
- Wrist Extensor Muscle Fatigue During a Dual Task With Two Muscular and Cognitive Load Levels in Younger and Older Adults.Human factors · 2024Article
- Black-white hole pattern: an investigation on the automated chronic neuropathic pain detection using EEG signals.Cognitive neurodynamics · 2024Article
- Fostering tissue engineering and regenerative medicine to treat musculoskeletal disorders in bone and muscle.Bioactive materials · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Musculoskeletal pain is a condition that characterises several diseases and represents a constantly growing issue with enormous socio-economic burdens, highlighting the importance of developing treatment algorithms appropriate to the patient's needs and effective management strategies. Indeed, the algic condition must be assessed and treated independently of the underlying pathological process since it has an extremely negative impact on the emotional and psychic aspects of the individual, leading to isolation and depression. A full understanding of the pathophysiological mechanisms involved in nociceptive stimulation and central sensitization is an important step in improving approaches to musculoskeletal pain. In this context, the bidirectional relationship between immune cells and neurons involved in nociception could represent a key point in the understanding of these mechanisms. Therefore, we provide an updated overview of the magnitude of the musculoskeletal pain problem, in terms of prevalence and costs, and summarise the role of the most important molecular players involved in the development and maintenance of pain. Finally, based on the pathophysiological mechanisms, we propose a model, called the "musculoskeletal pain cycle", which could be a useful tool to counteract resignation to the algic condition and provide a starting point for developing a treatment algorithm for the patient with musculoskeletal pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.