Evidence map›Paper›PMID 35566723›Full record

ReviewJournal of clinical medicine2022

Lymph Nodes Evaluation in Rectal Cancer: Where Do We Stand and Future Perspective.

Alessandra Borgheresi, Federica De Muzio, Andrea Agostini, Letizia Ottaviani, Alessandra Bruno, Vincenza Granata, Roberta Fusco, Ginevra Danti, Federica Flammia, Roberta Grassi and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. PET/MRI is superior to PET/CT in detecting oesophago and gastric carcinomas: a meta-analysis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. MRI for Rectal Cancer: Updates and Controversies-AJR. American journal of roentgenology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Alessandra BorgheresiDepartment of Clinical, Special and Dental Sciences, University Politecnica delle Marche, 60121 Ancona, Italy.
Federica De MuzioDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, 86100 Campobasso, Italy.
Andrea AgostiniDepartment of Clinical, Special and Dental Sciences, University Politecnica delle Marche, 60121 Ancona, Italy.
Letizia OttavianiDepartment of Radiological Sciences, University Hospital Ospedali Riuniti, 60126 Ancona, Italy.
Alessandra BrunoDepartment of Clinical, Special and Dental Sciences, University Politecnica delle Marche, 60121 Ancona, Italy.
Vincenza GranataDivision of Radiology, Istituto Nazionale Tumori IRCCS Fondazione Pascale IRCCS di Napoli, 80131 Naples, Italy.ORCID 0000-0002-6601-3221
Roberta FuscoMedical Oncology Division, Igea SpA, 80013 Napoli, Italy.
Ginevra DantiItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy.ORCID 0000-0002-7109-8119
Federica FlammiaDepartment of Radiology, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy.
Roberta GrassiItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy.
Francesca GrassiItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy.
Federico BrunoItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy.ORCID 0000-0002-1444-2585
Pierpaolo PalumboItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy.ORCID 0000-0003-1514-0092
Antonio BarileDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Vittorio MieleItalian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, 20122 Milan, Italy.ORCID 0000-0002-7848-1567
Andrea GiovagnoniDepartment of Clinical, Special and Dental Sciences, University Politecnica delle Marche, 60121 Ancona, Italy.
Marche Polytechnic University · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of L'Aquila · ITIGEA Clinical Biophysics (Italy) · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITSocietà Italiana di Reumatologia · ITUniversity of Molise · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The assessment of nodal involvement in patients with rectal cancer (RC) is fundamental in disease management. Magnetic Resonance Imaging (MRI) is routinely used for local and nodal staging of RC by using morphological criteria. The actual dimensional and morphological criteria for nodal assessment present several limitations in terms of sensitivity and specificity. For these reasons, several different techniques, such as Diffusion Weighted Imaging (DWI), Intravoxel Incoherent Motion (IVIM), Diffusion Kurtosis Imaging (DKI), and Dynamic Contrast Enhancement (DCE) in MRI have been introduced but still not fully validated. Positron Emission Tomography (PET)/CT plays a pivotal role in the assessment of LNs; more recently PET/MRI has been introduced. The advantages and limitations of these imaging modalities will be provided in this narrative review. The second part of the review includes experimental techniques, such as iron-oxide particles (SPIO), and dual-energy CT (DECT). Radiomics analysis is an active field of research, and the evidence about LNs in RC will be discussed. The review also discusses the different recommendations between the European and North American guidelines for the evaluation of LNs in RC, from anatomical considerations to structured reporting.

Indexed as

diffusion-weighted imagingmagnetic resonance imagingnodal stagingrectal cancer

Identifiers

PMID35566723
PMCPMC9104021
OpenAlexW4229005285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.