Evidence map›Paper›PMID 35566671›Full record

ArticleJournal of clinical medicine2022

Antibodies towards TVLLPVIFF Amino Acid Sequence of TNF Receptor Induced by

Weronika Gonciarz, Agata Tomaszewska, Agnieszka Krupa, Tomasz Rechciński, Maciej Chałubiński, Marlena Broncel, Magdalena Chmiela

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Weronika GonciarzDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12-16, 90-237 Lodz, Poland.ORCID 0000-0002-5231-5341
Agata TomaszewskaDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12-16, 90-237 Lodz, Poland.ORCID 0000-0003-4290-4115
Agnieszka KrupaDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12-16, 90-237 Lodz, Poland.ORCID 0000-0003-1303-4608
Tomasz RechcińskiClinic and Department of Cardiology, Medical University of Lodz, 92-213 Lodz, Poland.ORCID 0000-0001-7800-785X
Maciej ChałubińskiDepartment of Immunology and Allergy, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland.
Marlena BroncelLaboratory of Tissue Immunopharmacology, Department of Internal Diseases and Clinical Pharmacology, Medical University of Lodz, Kniaziewicza 1/5, 91-347 Lodz, Poland.
Magdalena ChmielaDepartment of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Łódź, Banacha 12-16, 90-237 Lodz, Poland.
University of Łódź · PLMedical University of Lodz · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular mimicry between

aimTo examine whether anti-P1 IgG are induced during Hp infection in CHD patients.

methodsSera from CHD patients infected with Hp (54) vs. sera of uninfected healthy donors (22) were tested by the ELISA for anti-

resultsSera of 43 CHD patients seropositive for anti-Hp IgG contained anti-P1 IgG binding C1q. Additionally, 10 serum samples of animals seropositive for anti-Hp IgG contained anti-P1 IgG. Anti-P1 IgG in tested sera were neutralized by their adsorption with Hp.

conclusionIn CHD patients infected with Hp, antibodies cross-reacting with TNFR common sequence are produced. Further studies are necessary to define immunogenic Hp determinants and to confirm possible cellular effects of cross-reacting antibodies.

Indexed as

antigenic mimicryatherogenesisHelicobacter pylorihuman TNFR

Identifiers

PMID35566671
PMCPMC9103578
OpenAlexW4225255176

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.