Evidence map›Paper›PMID 35566643›Full record

ArticleJournal of clinical medicine2022

Clinical Evaluation of the Efficacy and Tolerability of Rigenase

Raffaele Russo, Albino Carrizzo, Alfonso Barbato, Barbara Rosa Rasile, Paola Pentangelo, Alessandra Ceccaroni, Caterina Marra, Carmine Alfano, Luigi Losco

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Efficacy of a Novel RigenaseMedicina (Kaunas, Lithuania) · 2023
    Observational
  13. Article
  14. Advances in Translational Regenerative Therapies.Journal of clinical medicine · 2023
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Raffaele RussoPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Albino CarrizzoPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.ORCID 0000-0003-2689-0008
Alfonso BarbatoU.O.C. di Chirurgia Plastica Ricostruttiva, Azienda Ospedaliera Universitaria OO.RR. San Giovanni di Dio e Ruggi d'Aragona, Via S. Leonardo 1, 84131 Salerno, Italy.
Barbara Rosa RasilePlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Paola PentangeloPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Alessandra CeccaroniPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Caterina MarraPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Carmine AlfanoPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.
Luigi LoscoPlastic Surgery Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, 84081 Salerno, Italy.ORCID 0000-0001-9105-1839
University of Salerno · ITOspedali Riuniti San Giovanni di Dio e Ruggi d'Aragona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCompare the efficacy and tolerability of Connettivina

designSingle-center, parallel, randomized trial. A block randomization method was used.

settingUniversity of Salerno-AOU San Giovanni di Dio e Ruggi d'Aragona.

participantsSixty patients were enrolled. All patients fulfilled the study requirements.

interventionOne application of the study drugs every 24 h, and a six-week observation period.

main outcome measuresEfficacy and tolerability of the study drugs.

resultsIn total, 60 patients (Group A,

conclusionsBoth Connettivina

Indexed as

acute skin woundaqueous extract of Triticum vulgareConnettivina Bio PlusFitostimoline Plushyaluronic acidrandomized trialRigenaseTVEwound healing

Identifiers

PMID35566643
PMCPMC9105357
OpenAlexW4225135500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.