ArticleJournal of clinical medicine2022
Alveolar Bone Remodeling with or without Collagen Filling of the Extraction Socket: A High-Resolution X-ray Tomography Animal Study.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Tomographic assessment of bone changes in atrophic maxilla treated by split-crest technique and dental implants with platelet-rich fibrin and NanoBoneBMC oral health · 2024Trial
- Neuroimmune Regulation in Posttraumatic Bone Repair: From Inflammatory Transition to Neurovascular Coupling and Functional Recovery.Journal of cellular physiology · 2026Review
- Virtual and clinical implant placement after ridge preservation in periodontally compromised molars: retrospective study.BMC oral health · 2026Article
- Dentinal Grafts, a Promising Material for Alveolar Defects: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Randomized controlled trial of immediate alveolar ridge preservation for bone and soft tissue aesthetics after tooth extraction.Frontiers in surgery · 2026Article
- Comparative Evaluation of Hyaluronic Acid (hyaDENT BGJournal of functional biomaterials · 2025Article
- Association between bone turnover markers and alveolar socket healing rate: A cross-sectional study.Oral and maxillofacial surgery · 2025Article
- Alveolar bone regeneration using sustainable eggshell-derived nano-hydroxyapatite and zinc oxide nanoparticles: an in vivo experimental study.Scientific reports · 2025Article
- Bone augmentation effect of implant apex flush with maxillary sinus notch in transcrestal sinus floor elevation: A retrospective study.Clinical oral investigations · 2025Article
- Insights into the Current Management Techniques for Peri-Implant Gaps: A Systematic Review.Journal of clinical medicine · 2025Review
- Peri-Implant Architecture Management With Customized Healing Abutment in Flowable Composite in Immediate Implants: Two Case Reports and Narrative Review.Case reports in dentistry · 2025Article
- Survival analysis of dental implants placed in horizontally severely resorbed maxillae after reconstruction with xenogeneic graft: a case series.Oral and maxillofacial surgery · 2024Article
- Article
- Anatomical Factors of the Anterior and Posterior Maxilla Affecting Immediate Implant Placement Based on Cone Beam Computed Tomography Analysis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Use of autologous tooth-derived material as a graft in the post-extraction socket. Split-mouth study with radiological and histological analysis.BMC oral health · 2024Article
- Thermal implant removal in a pig jaw: a proof of concept study.Clinical oral investigations · 2024Article
- Melatonin Decreases Alveolar Bone Loss in Rats with Experimental Periodontitis and Osteoporosis: A Morphometric and Histopathologic Study.Biomedicines · 2024Article
- Appreciable biosafety, biocompatibility and osteogenic capability of 3D printed nonstoichiometric wollastonite scaffolds favorable for clinical translation.Journal of orthopaedic translation · 2024Article
- Current Knowledge on the Healing of the Extraction Socket: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Evaluation of a Granular Bone Substitute for Bone Regeneration Using an Optimized In Vivo Alveolar Cleft Model.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The healing process of the tooth extraction socket often leads to significant resorption of the alveolar bone, eventually causing clinical difficulties for future implant-supported rehabilitations. The aim of the present animal study was to evaluate alveolar bone remodeling after tooth extraction in a rabbit model, either with or without the use of a plain collagen plug inside the socket, by means of micro-computed tomography. The study included the micro-tomography analysis of 36 rabbits' incisor extraction sockets, either left empty or filled with a collagen plug. All animals were euthanized in a staggered manner, in order to address molecular, histologic, and radiographic analyses at different time-points, up to 90 days after surgery. The three-dimensional evaluation was carried out using micro-computed tomography technology on excised bone blocks including the alveolus and the contralateral bone. Both linear and volumetric measures were recorded: the percentage of bone volume change (ΔBV) within the region of interest was considered the primary endpoint of the study. The micro-CT analysis revealed mean volumetric changes of -58.1% ± from baseline to 3 months for the control group, and almost no bone loss for the test group, -4.6%. The sockets treated with the collagen plug showed significantly less dimensional resorption, while the natural-healing group showed an evident collapse of the alveolar bone three months after extraction surgery.
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