ArticleJournal of clinical medicine2022
Abnormal Dorsal Caudate Activation Mediated Impaired Cognitive Flexibility in Mild Traumatic Brain Injury.
Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury.Frontiers in neuroscience · 2026Pooled it
- Neuroanatomical restoration of salience network links reduced headache impact to cognitive function improvement in mild traumatic brain injury with posttraumatic headache.The journal of headache and pain · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMild traumatic brain injury (mTBI) is an important but less recognized public health concern. Previous studies have demonstrated that patients with mTBI have impaired executive function, which disrupts the performance of daily activities. Few studies have investigated neural mechanisms of cognitive flexibility in mTBI patients using objective tools such as the psychological experiment paradigm. Here, we aimed to examine neural correlates of cognitive flexibility in mTBI.
methodsSixteen mTBI patients and seventeen matched healthy controls (HCs) underwent functional MRI during a rule-based task-switching experimental paradigm. Linear models were used to obtain within-group activation maps and areas of differential activation between the groups. In addition, we conducted mediation analyses to evaluate the indirect effect of abnormal dorsal caudate activation on the association between information processing speed and cognitive flexibility in mTBI.
resultsmTBI patients exhibited significantly longer reaction time in the task switching (TS) condition compared to HCs, reflecting impaired cognitive flexibility. In addition, the patients showed reduced activation in the dorsal caudate (dCau), anterior cingulate cortex, and other frontal regions during the TS condition. Mediation analysis revealed that the reduced dCau activation had a significant effect on the relationship between information processing speed and cognitive flexibility in mTBI.
conclusionsAbnormal dorsal caudate activation in mTBI mediates impaired cognitive flexibility, which indicated dorsal caudate might be playing a vital role in the cognitive flexibility of mTBI patients. These findings highlight an alternative target for clinical interventions for the improvement of cognitive functions in mTBI.
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